| Record ID | marc_columbia/Columbia-extract-20221130-008.mrc:544126863:2715 |
| Source | marc_columbia |
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LEADER: 02715cam a2200361 a 4500
001 3980906
005 20221027013101.0
008 930113t19941994enka b 001 0 eng
010 $a 93002766
020 $a0521382998
035 $a(OCoLC)ocm27430412
035 $9AJA0693HS
035 $a(NNC)3980906
035 $a3980906
040 $aDLC$cDLC$dCOU$dNGU
050 00 $aQP86$b.K335 1994
082 00 $a612.6/7$220
100 1 $aKanungo, M. S.$q(Madhu Sudan),$d1927-$0http://id.loc.gov/authorities/names/n93003989
245 10 $aGenes and aging /$cM.S. Kanungo.
260 $aCambridge ;$aNew York, N.Y., USA :$bCambridge University Press,$c[1994], ©1994.
300 $axii, 322 pages :$billustrations ;$c24 cm
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
504 $aIncludes bibliographical references (p. 290-319) and index.
505 0 $a1. Introduction -- 2. Phenotypic changes during aging -- 3. Chromatin -- 4. Eukaryotic genes -- 5. Changes in gene expression during aging -- 6. Theories of aging -- 7. Conclusions and future prospects.
520 $aThe maximum life span of multicellular organisms varies greatly: for a fruitfly it is about 30 days, for a dog about 20 years, and for a human about 100 years. Despite these differences, all animals show a similar pattern in their life spans - growth, adulthood, and aging, followed by death. The basic cause of aging in multicellular organisms (eukaryotes) lies at the level of the genes, although nutrition and various types of stresses do influence the rate and pattern of aging.
520 8 $aThis book reviews the molecular biology of the gene in relation to aging. Until about a decade ago it was not possible to probe into the types of changes that occur in eukaryotic genes, due to their enormous complexity The use of genetic engineering techniques, however, is beginning to unravel the changes that occur in the genes as an organism ages: such as the changing expression of specific genes under normal conditions and under various types of stress, the changes in the regulatory roles of the sequences in the promoter regions of genes, conformational changes that may occur in genes during aging, and the protein factors that are involved in the aging process.
650 0 $aAging$xGenetic aspects.$0http://id.loc.gov/authorities/subjects/sh85002204
650 0 $aCells$xAging.$0http://id.loc.gov/authorities/subjects/sh85021680
650 2 $aAging$xgenetics.$0https://id.nlm.nih.gov/mesh/D000375Q000235
650 2 $aCellular Senescence.$0https://id.nlm.nih.gov/mesh/D016922
650 2 $aEukaryotic Cells$xphysiology.$0https://id.nlm.nih.gov/mesh/D005057Q000502
852 00 $boff,hsl$hQP86$i.K335 1994