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001 ocn856590343
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008 130822s2013 sz ob 000 0 eng d
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020 $a9783034806640$q(electronic bk.)
020 $a3034806647$q(electronic bk.)
020 $a3034806639$q(hard cover ;$qalk. paper)
020 $a9783034806633$q(hard cover ;$qalk. paper)
020 $z9783034806633
024 7 $a10.1007/978-3-0348-0664-0$2doi
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037 $bSpringer
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100 1 $aMaximov, Philipp Y.
245 10 $aTamoxifen :$bpioneering medicine in breast cancer /$cPhilipp Y. Maximov, Russell E. McDaniel, V. Craig Jordan.
260 $aBasel ;$aNew York :$bSpringer,$c©2013.
300 $a1 online resource
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
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347 $atext file
347 $bPDF
490 1 $aMilestones in drug therapy
505 00 $tDiscovery and Pharmacology of Nonsteroidal Estrogens and Antiestrogens --$tTamoxifen Goes Forward Alone --$tMetabolites of Tamoxifen as the Basis of Drug Development --$tAdjuvant Therapy: The Breakthrough --$tThe Wisconsin Story in the 1980s: Discovery of Target Site-Specific Estrogen Action --$tCarcinogenesis and Tamoxifen --$tChemoprevention: Cinderella Waiting for the Ball --$tTamoxifen and Raloxifene Head to Head: The STAR Trial --$tAcquired Resistance to Tamoxifen: Back to the Beginning --$tThe Legacy of Tamoxifen.
504 $aIncludes bibliographical references.
520 $aTamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the "father of tamoxifen"--And his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a "failed morning after contraceptive" to become the "gold standard" for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen's pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis
546 $aEnglish.
650 0 $aTamoxifen.
650 0 $aBreast$xCancer$xChemotherapy.
650 12 $aTamoxifen
650 22 $aBreast Neoplasms$xdrug therapy
650 6 $aTamoxifène.
650 6 $aSein$xCancer$xChimiothérapie.
650 7 $aHEALTH & FITNESS$xDiseases$xGeneral.$2bisacsh
650 7 $aMEDICAL$xClinical Medicine.$2bisacsh
650 7 $aMEDICAL$xDiseases.$2bisacsh
650 7 $aMEDICAL$xEvidence-Based Medicine.$2bisacsh
650 7 $aMEDICAL$xInternal Medicine.$2bisacsh
650 7 $aBreast$xCancer$xChemotherapy.$2fast$0(OCoLC)fst00838266
650 7 $aTamoxifen.$2fast$0(OCoLC)fst01142573
655 0 $aElectronic books.
655 4 $aElectronic books.
700 1 $aMcDaniel, Russell E.
700 1 $aJordan, V. Craig$q(Virgil Craig)
776 08 $iPrint version:$aMaximov, Philipp Y.$tTamoxifen : Pioneering Medicine in Breast Cancer.$dDordrecht : Springer, ©2013$z9783034806633
830 0 $aMilestones in drug therapy.
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