MARC record from Internet Archive

LEADER: 04259cam 2200745 a 4500
001 ocn191954428
003 OCoLC
005 20210507075932.0
008 080212s2007 au a b i000 0 eng
040 $aNz$beng$cNLM$dNZLNU$dORE$dCOD$dSINLB$dBTCTA$dYDXCP$dOCLCF$dBEDGE$dOCLCQ$dOCLCO$dV5E$dUKMGB$dNLM$dOCLCO$dOCLCA$dOCLCQ
016 7 $a101627187$2DNLM
016 7 $a014516316$2Uk
019 $a457166225
020 $a9789201016072
020 $a9201016077
035 $a(OCoLC)191954428$z(OCoLC)457166225
042 $anlmcopyc
050 4 $aQC770$b.I56 no.459
060 00 $a2015 E-765
060 10 $aWN 25
080 $a616-073$bL33
082 04 $a539.7$222
245 00 $aLabelling of small biomolecules using novel technetium-99m cores.
260 $aVienna, Austria :$bInternational Atomic Energy Agency,$c2007.
300 $a311 pages :$billustrations ;$c24 cm.
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
338 $avolume$bnc$2rdacarrier
490 1 $aTechnical reports series,$x0074-1914 ;$vno. 459
500 $a"STI/DOC/010/459"--Title page verso.
504 $aIncludes bibliographical references.
505 2 $apt. 1. Overview of the coordinated research project -- pt. 2. Reports by the participants in the coordinated research project.
520 $aTechnetium-99m radiopharmaceuticals account for nearly 80% of all diagnostic studies done in nuclear medicine. The ability to determine the exact molecular structure of the coordination compounds by using modern powerful analytical tools such as NMR, mass spectroscopy and X ray diffraction has contributed to the understanding of the structure-activity relationships underlying the biological behavior of Tc-99m agents. Consequently, careful design of new ligands and their Tc-99m complexes led to the discovery of imaging agents for perfusion in the myocardium and brain, thereby extending the scope of diagnostic imaging using Tc-99m radiopharmaceuticals. Based on the new developments in Tc chemistry, there is good scope for the development of new radiopharmaceuticals for imaging cancer as well as certain specific disease conditions. The IAEA organized a Coordinated Research Project (CRP) with the specific objective to develop labelled biomolecules with the novel Tc-99m metal cores such as the Tc-99m-Carbonyl, Tc-99m-Nitrido, Tc-99m (4+1) and Tc-99m-HYNIC cores. The preparation, quality assessment and biological evaluations of a large number of Tc-99m complexes with biomolecules such as RGD peptides, annexin derived peptides, fatty acid derivatives, quinazoline derivatives and glucose analogues were achieved by the participants during the CRP. The results obtained from the participating laboratories are summarized in this publication.--Publisher's description.
530 $aAlso issued online.
650 0 $aBiomolecules.
650 0 $aTechnetium.
650 0 $aRadiolabeling.
650 0 $aRadiopharmaceuticals.
650 12 $aIsotope Labeling$xmethods.
650 12 $aTechnetium.
650 22 $aMolecular Structure.
650 22 $aRadiopharmaceuticals.
650 7 $aMédecine nucléaire.$2eclas
650 7 $aBiologie moléculaire.$2eclas
650 7 $aProduits pharmaceutiques.$2eclas
650 7 $aProjets de recherche.$2eclas
650 7 $aBiomolecules.$2fast$0(OCoLC)fst00832624
650 7 $aRadiolabeling.$2fast$0(OCoLC)fst01088249
650 7 $aRadiopharmaceuticals.$2fast$0(OCoLC)fst01088327
650 7 $aTechnetium.$2fast$0(OCoLC)fst01144724
655 2 $aLaboratory Manual.
710 2 $aInternational Atomic Energy Agency.
830 0 $aTechnical reports series (International Atomic Energy Agency) ;$vno. 459.$x0074-1914
856 41 $uhttp://www-pub.iaea.org/MTCD/publications/PDF/trs459_web.pdf$zConnect to online resource
856 4 $uhttp://www-pub.iaea.org/MTCD/publications/PDF/trs459_web.pdf
938 $aBaker and Taylor$bBTCP$nBK0008604200
938 $aYBP Library Services$bYANK$n3791898
029 0 $aNLM$b101627187
029 1 $aAU@$b000042706349
029 1 $aAU@$b000046257847
029 1 $aDEBBG$bBV035782936
029 1 $aNZ1$b11623725
029 1 $aUKMGB$b014516316
994 $aZ0$bP4A
948 $hNO HOLDINGS IN P4A - 37 OTHER HOLDINGS