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LEADER: 07327cam 2200913Ia 4500
001 ocn185026869
003 OCoLC
005 20200430012821.0
008 071223s2007 gw a ob 001 0 eng d
006 m o d
007 cr cn|||||||||
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024 7 $a10.1007/978-3-540-71329-6$2doi
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037 $a978-3-540-71328-9$bSpringer$nhttp://www.springerlink.com
050 4 $aQR1$b.E6eb vol. 316
060 4 $aW1$bCU82K v.316 2007
060 4 $aQW 800$bI618 2007
070 $aQR187.5$b.I62 2007
072 7 $aSCI$x056000$2bisacsh
072 7 $aMJCM$2bicssc
082 04 $a616.07/91$222
084 $aR978. 7$2clc
245 00 $aInterferon :$bthe 50th anniversary /$cPaula M. Pitha, ed.
260 $aBerlin :$bSpringer,$c℗♭2007.
300 $a1 online resource (vi, 391 pages) :$billustrations
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
347 $atext file$bPDF$2rda
490 1 $aCurrent topics in microbiology and immunology,$x0070-217X ;$v316
504 $aIncludes bibliographical references and index.
520 $aOver the last half of century interferon (IFN), originally discovered as an antiviral protein, has developed from an inhibitor of viral replication to a major force in the antiviral response. Initially studied only by few virologists, IFN was generally considered as a poorly defined protein of limited importance. The development of molecular techniques lead to the identification of a family of IFN genes and has shown an unexpected complexity of type I IFN genes and their expression. Presently, some aspects of the of the pathogen mediated induction of IFN gene expression are understood at molec.
588 0 $aPrint version record.
505 0 $aRefletions -- How to Chase a Red Herring and Come up with a Smallmouth Bass -- Interferon Research BC (Before Cloning) -- Purification and Cloning of Interferon Alpha -- Interferons and Their Signaling Pathways -- Type I Interferon: The Ever Unfolding Story -- The Receptor of the Type I Interferon Family -- IFN-?: Recent Advances in Understanding Regulation of Expression, Biological Functions, and Clinical Applications -- Cell Type-Specific Signaling in Response to Interferon-? -- Interferon Research: Impact on Understanding Transcriptional Control -- Recognition of Pathogens, Molecular Mechanism of Interferon Beta Induction -- TLR-Mediated Activation of Type I IFN During Antiviral Immune Responses: Fighting the Battle to Win the War -- Regulation of Antiviral Innate Immune Responses by RIG-I Family of RNA Helicases -- Beyond Double-Stranded RNA-Type I IFN Induction by 3pRNA and Other Viral Nucleic Acids -- Interferon-Induced Genes -- The Interferon-Stimulated Genes: Targets of Direct Signaling by Interferons, Double-Stranded RNA, and Viruses -- Structure and Function of the Protein Kinase R -- Virus Defense -- Viral Regulation and Evasion of the Host Response -- Pathogenic Viruses: Smart Manipulators of the Interferon System -- Role of Interferon in Viral Infection and Autoimmunity -- Type I Interferon During Viral Infections: Multiple Triggers for a Multifunctional Mediator -- Type I Interferon in Systemic Lupus Erythematosus.
650 0 $aInterferon.
650 12 $aInterferon Type I.
650 7 $aSCIENCE$xLife Sciences$xAnatomy & Physiology.$2bisacsh
650 07 $aInterferon.$2cct
650 7 $aBiome decine.$2eclas
650 7 $aSciences de la vie.$2eclas
650 7 $aInterferon.$2fast$0(OCoLC)fst00976239
655 4 $aElectronic books.
700 1 $aPitha, Paula M.
773 0 $tSpringer e-books
776 08 $iPrint version:$tInterferon.$dBerlin : Springer, ℗♭2007$z9783540713289$z354071328X$w(DLC) 72152360$w(OCoLC)149006967
830 0 $aCurrent topics in microbiology and immunology ;$v316.$x0070-217X
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