MARC record from Internet Archive

LEADER: 07090cam 2200829 a 4500
001 ocm35262289
003 OCoLC
005 20200519215741.0
008 960802s1997 nyua b 001 0 eng
010 $a 96033491
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015 $aGB9735146$2bnb
016 7 $a9714252$2DNLM
019 $a37268370
020 $a0471596442$q(acid-free paper)
020 $a9780471596448$q(acid-free paper)
035 $a(OCoLC)35262289$z(OCoLC)37268370
050 00 $aRS429$b.I48 1997
060 00 $a1997 I-481
060 10 $aQV 744$bI31 1997
082 00 $a615/.7$220
084 $a44.38$2bcl
084 $aVS 5350$2rvk
245 04 $aThe impact of stereochemistry on drug development and use /$c[edited by] Hassan Y. Aboul-Enein and Irving W. Wainer.
260 $aNew York :$bWiley,$c℗♭1997.
300 $axxvii, 695 pages :$billustrations ;$c24 cm.
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
338 $avolume$bnc$2rdacarrier
490 1 $aChemical analysis ;$vv. 142
500 $aSeries no. on spine 134 [sic].
500 $a"A Wiley-Interscience publication."
504 $aIncludes bibliographical references and index.
505 0 $aChirality and drug hazards / Hassan Y. Aboul-Enein and Laila I. Abou Basha -- Stereochemistry in the drug development process : role of chirality as a determinant of drug action, metabolism, and toxicity / Thomas A. Baillie and Kathleen M. Schultz -- Stereochemical aspects of drug metabolism / Jonathan P. Mason and Andrew J. Hutt -- Some examples for stereoselective biotransformation of drugs / Gottfried Blaschke -- Kinetics of reactive phase II metabolites : stereochemical aspects of formation of epimeric acyl glucuronides and their reactivity / Hildegard Spahn-Langguth [and others] -- Studies on the stereoselectivity of the biologically important metabolism of alkene-alkene oxide (oxirane)-alkanediol / Dorothee Wistuba -- Chiral barbiturates : synthesis, chromatographic resolutions, and biological activity / Jacek Bojarski -- Ethambutol and tuerculosis, a neglected and confused chiral puzzle / Bernard Blessington -- Stereogenic elements of pharmaceutical compounds : some aspects on isomerism, resolution, and stereochemical integrity / Stig G. Allen Mark -- The importance of chiral separations in pharmaceuticals / Sut Ahuja -- Separation of optically active pharmaceuticals using capillary electrophoresis / Timothy J. Ward and Karen D. Ward -- Chiral recognition mechanism of polysaccharides chiral stationary phases / Eji Yashima and Yoshio Okamoto -- Michelle-mediated capillary electrophoretic separation of enantomeric compounds / Michael E. Swartz and Phyllis R. Brown -- Unified enantioselective chromatography involving chirasil-dex / Volker Schurig [and others] -- Derivatized cyclodextrins as chiral gas chromatographic stationary phases and their potential applications in the pharmaceutical industry / Weiyong Li and Thomas M. Rossi -- Chiral derivatization reagents in the bioanalysis of optically active drugs with chromophore-based detection / Ralf Bu schges [and others] -- Circular dichroism spectroscopy in the analysis of chiral drugs / Piera Salvadori, Carlo Rosini, and Carlo Bertucci -- Circular Dichroism in the study of stereoselective binding of drugs to serum proteins / Carlo Bertucci, Piero Salvadori, and Enrico Domenici -- Current regulatory guidelines of stereoisomeric drugs : North American, European, and Japanese point of view / Sylvie Laganie re -- Enantioselective analysis and the regulation of chiral drugs / Michael Gross -- First pass phenomena : sources of stereoselectives and variabilities of concentration-time profiles after oral dosage / Hildegard Spahn-Langguth [and others] -- Gastrointestinal transport processes : potentials for stereoselectivities at substrate-specific and nonspecific epithelial transport systems / Peter Langguth -- Preparation of drug enantiomers by chromatographic resolution on chiral stationary phases / Eric Francotte.
520 $aThe book explores analytical, pharmacological, and regulatory topics in dealing with the theory and practice of stereochemistry in the pharmarceutical industry today. This exciting, broad-appeal treatment extends from the analytical viewpoint in enantiomeric separation to the regulatory issues involved in the "racemate-versus-enantiomer" debate. The authors include numerous examples and case studies, and integrate material from a wide range of studies, publications, and workshops. The Impact of Stereochemistry on Drug Development and Use is an essential reference for medicinal and analytical chemists, pharmacologists, drug metabolism and pharmacokinetic scientists, and personnel of regulatory agencies. It is also a useful text for graduate students in stereochemistry, and for anyone who wants to keep up with the swift pace of change in this dynamic field.
650 0 $aChiral drugs.
650 12 $aChemistry, Pharmaceutical$xmethods.
650 22 $aMolecular Conformation.
650 22 $aStereoisomerism.
650 6 $aMe dicaments chiraux.
650 7 $aChiral drugs.$2fast$0(OCoLC)fst00857866
650 7 $aSte re oisome rie.$2fmesh
650 7 $aChimie analytique.$2fmesh
650 7 $aArzneimittel$2gnd
650 7 $aStereochemie$2gnd
650 7 $aStruktur-Aktivita ts-Beziehung$2gnd
650 7 $aSte re ochimie.$2ram
650 7 $aChiralite $xEmploi en the rapeutique.$2ram
650 7 $aE nantiome res$xSe paration.$2ram
650 7 $aMe dicaments.$2ram
650 7 $aE nantiome res$xSynthe se.$2ram
700 1 $aAboul-Enein, Hassan Y.
700 1 $aWainer, Irving W.
776 08 $iOnline version:$tImpact of stereochemistry on drug development and use.$dNew York : Wiley, ℗♭1997$w(OCoLC)645945239
830 0 $aChemical analysis ;$vv. 142.
856 41 $3Table of contents$uhttp://catdir.loc.gov/catdir/toc/onix04/96033491.html
856 41 $3Table of contents$uhttp://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007634791&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
856 42 $3Contributor biographical information$uhttp://catdir.loc.gov/catdir/bios/wiley042/96033491.html
856 42 $3Publisher description$uhttp://catdir.loc.gov/catdir/description/wiley033/96033491.html
856 42 $3The Class of 1932 Fund Home Page$uhttp://hdl.library.upenn.edu/1017.12/366302
938 $aBaker & Taylor$bBKTY$c180.00$d180.00$i0471596442$n0002905088$sactive
938 $aBrodart$bBROD$n50571435$c$209.95
938 $aBaker and Taylor$bBTCP$n96033491
938 $aYBP Library Services$bYANK$n1339187
029 1 $aAU@$b000012665390
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029 1 $aNLM$b9714252
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948 $hNO HOLDINGS IN P4A - 233 OTHER HOLDINGS