MARC record from Internet Archive

LEADER: 08249cam 2200997Ia 4500
001 ocn162579081
003 OCoLC
005 20200521211739.0
008 070806s2003 ne a ob 001 0 eng d
006 m o d
007 cr cn|||||||||
040 $aOPELS$beng$epn$cOPELS$dBAKER$dDEBSZ$dOPELS$dOCLCQ$dOCLCF$dOCLCE$dOCLCO$dYDXCP$dOCLCQ$dCASUM$dOCLCQ$dUAB$dOCLCO$dCNCGM$dOCLCA$dKIJ$dD6H$dOCLCQ$dOCLCO$dOCLCA$dLEAUB$dOL$$dOCLCA
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020 $a9780444510297
020 $a044451029X
020 $a9780080533964
020 $a0080533965
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037 $a91388:91385$bElsevier Science & Technology$nhttp://www.sciencedirect.com
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060 4 $aW1$bPR677LM v.5 2003
060 4 $aQV 771$bW453h 2003
082 04 $a615.1901$222
084 $aCHE 808f$2stub
084 $aCIT 680f$2stub
100 1 $aWells, David A.
245 10 $aHigh throughput bioanalytical sample preparation :$bmethods and automation strategies /$cDavid A. Wells.
250 $a1st ed.
260 $aAmsterdam ;$aBoston :$bElsevier,$c2003.
300 $a1 online resource (xxx, 610 pages) :$billustrations.
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
490 1 $aProgress in pharmaceutical and biomedical analysis ;$vv. 5
520 $aHigh Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies is an authoritative reference on the current state-of-the-art in sample preparation techniques for bioanalysis. This book focuses on high throughput (rapid productivity) techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A thorough review of the literature is included within each of these chapters describing high throughput sample preparation techniques: protein removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase extraction; and various on-line techniques. The text begins with an introductory overview of the role of bioanalysis in pharmaceutical drug development. Fundamental understanding of the strategies for sample preparation is reinforced next, along with essential concepts in extraction chemistry. Several chapters introduce and discuss microplates, accessory products and automation devices. Particular strategies for efficient use of automation within a bioanalytical laboratory are also presented. The subject material then reviews protein precipitation, liquid-liquid extraction, solid-phase extraction and various on-line sample preparation approaches. The book concludes with information on recent advances in sample preparation, such as solid-phase extraction in a card format and higher density extraction plates. Important objectives that can be accomplished when the strategies presented in this book are followed include: improved efficiency in moving discovery compounds to preclinical status with robust analytical methods; return on investment in automation for sample preparation; and improved knowledge and expertise of laboratory staff. Shows the reader exactly how to perform modern bioanalytical sample preparation techniques, complete with detailed strategies Thorough literature review and summary of published information Detailed discussion and examples of the method development process.
505 0 $aChapter 1. Role of Bioanalysis in Pharmaceutical Drug Development -- Chapter 2. Fundamental Strategies for Bioanalytical Sample Preparation -- Chapter 3. High Throughput Tools for Bioanalysis: Microplates -- Chapter 4. High Throughput Tools for Bioanalysis: Accessory Products -- Chapter 5. Automation Tools and Strategies for Bioanalysis -- Chapter 6. Protein Precipitation: High Throughput Techniques and Strategies for Method Development -- Chapter 7. Protein Precipitation: Automation Strategies -- Chapter 8. Liquid-Liquid Extraction: High Throughput Techniques -- Chapter 9. Liquid-Liquid Extraction: Strategies for Method Development -- and Optimization -- Chapter 10. Liquid-Liquid Extraction: Automation Strategies -- Chapter 11. Solid-Phase Extraction: High Throughput Techniques -- Chapter 12. Solid-Phase Extraction: Strategies for Method Development and Optimization -- Chapter 13. Solid-Phase Extraction: Automation Strategies -- Chapter 14. On-Line Sample Preparation: High Throughput Techniques and Strategies for Method Development -- Chapter 15. Advances in Sample Preparation for Bioanalysis.
504 $aIncludes bibliographical references and index.
588 0 $aPrint version record.
506 $3Use copy$fRestrictions unspecified$2star$5MiAaHDL
533 $aElectronic reproduction.$b[S.l.] :$cHathiTrust Digital Library,$d2010.$5MiAaHDL
538 $aMaster and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.$uhttp://purl.oclc.org/DLF/benchrepro0212$5MiAaHDL
583 1 $adigitized$c2010$hHathiTrust Digital Library$lcommitted to preserve$2pda$5MiAaHDL
650 0 $aDrugs$xAnalysis.
650 0 $aPharmaceutical industry$xTechnological innovations.
650 02 $aBody Fluids.
650 02 $aChemistry, Analytical$xinstrumentation.
650 02 $aDrug Evaluation, Preclinical$xinstrumentation.
650 02 $aDrug Evaluation, Preclinical$xmethods.
650 02 $aDrug Industry.
650 02 $aPharmaceutical Preparations.
650 02 $aPharmaceutical Preparations$xanalysis.
650 02 $aPharmaceutical Preparations$xmetabolism.
650 6 $aMédicaments$xAnalyse.
650 6 $aIndustrie pharmaceutique$xInnovations.
650 6 $aPharmacocinétique.
650 7 $aDrugs$xAnalysis.$2fast$0(OCoLC)fst00898769
650 7 $aPharmaceutical industry$xTechnological innovations.$2fast$0(OCoLC)fst01060184
650 7 $aAnalytische Chemie$2gnd
650 7 $aBiochemische Analyse$2gnd
650 7 $aBiologisches Material$2gnd
650 7 $aHigh throughput screening$2gnd
650 7 $aProbenvorbereitung$2gnd
650 07 $aAutomation.$2swd
655 2 $aElectronic information resources.
655 4 $aElectronic books.
655 0 $aElectronic books.
776 08 $iPrint version:$aWells, David A.$tHigh throughput bioanalytical sample preparation.$b1st ed.$dAmsterdam ; Boston : Elsevier, 2003$z044451029X$z9780444510297$w(DLC) 2003273598$w(OCoLC)51108551
830 0 $aProgress in pharmaceutical and biomedical analysis ;$vv. 5.
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856 40 $3ScienceDirect$uhttp://www.sciencedirect.com/science/publication?issn=14643456&volume=5
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856 40 $3ScienceDirect$uhttp://dproxy.library.dc-uoit.ca/login?url=https://www.sciencedirect.com/science/bookseries/14643456/5
856 42 $3Publisher description$uhttp://catdir.loc.gov/catdir/description/els041/2003273598.html
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