MARC record from Internet Archive

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001 ocn162569825
003 OCoLC
005 20200424030642.0
008 070806s2006 ne a ob 001 0 eng d
006 m o d
007 cr cn|||||||||
010 $a 2006271885
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019 $a76838309$a647545517$a989301056$a1011235235$a1024250675
020 $a9780120884452
020 $a0120884453
020 $a0080456987$q(electronic bk.)
020 $a9780080456980$q(electronic bk.)
035 $a(OCoLC)162569825$z(OCoLC)76838309$z(OCoLC)647545517$z(OCoLC)989301056$z(OCoLC)1011235235$z(OCoLC)1024250675
037 $a107503:107539$bElsevier Science & Technology$nhttp://www.sciencedirect.com
050 4 $aQP632.B3$bC65 2006eb
060 4 $a2006 B-347
060 4 $aQW 630.5.B2$bC737 2006
070 $aQP632.B3$bC65 2006
072 7 $aMED$x096000$2bisacsh
082 04 $a615.9/5293$222
082 04 $a616.9201$222
245 04 $aThe comprehensive sourcebook of bacterial protein toxins /$ceditors, Joseph E. Alouf and Michel R. Popoff.
246 30 $aBacterial protein toxins
250 $a3rd ed.
260 $aAmsterdam ;$aBoston :$bElsevier,$c℗♭2006.
300 $a1 online resource (xxiii, 1047 pages) :$billustrations
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
520 $aBacterial toxins play an important role in infectious diseases. Several are amongst the most potent biological agents known to man. Cholera, pertussis, botulinum, clostridium and tetanus toxins are all produced by bacteria. In many cases, it is the toxin produced and not the infectious agent itself that causes pathology. Botulinum toxin has now of course found clinical application as botox, and anthrax, and other toxins, have potentially devastating effects if misused as an agent of biological terror. This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century, illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. * Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France * 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology * Includes the major toxins of both basic and clinical interest are described in depth * Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology * Evolutionary and functional aspects of bacterial toxins evaluated and summarized * Toxin applications in cell biology presented * Therapy (cancer therapy, dystonias) discussed * Vaccines (native and genetically engineered vaccines) featured * Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.
505 0 $aIntroduction -- A 116-year story of bacterial protein toxins (1888-2004): From diphtheritic poison to molecular toxinology -- Evolutionary aspects of toxin-producing bacteria -- Mobile genetic elements and pathogenicity islands encoding bacterial toxins -- Regulation systems of toxin expression -- Toxin secretion systems -- Intracellular trafficking of bacterial protein toxins -- Translocation of bacterial protein toxin into the cytosol -- Bacterial toxins and virulence factors targeting the actin cytoskeleton and -- intracellular junctions -- Bacterial toxins and mitochondria -- Toxins activating RHO GTPases and exploiting the cellular ubiquitin/proteasome -- machineries -- Toxin receptors -- Molecular, functional and evolutionary aspects of ADP-ribosylating toxins -- Diphtheria toxin -- Attack of the nervous system by clostridial toxins: Physical findings, cellular and -- molecular actions -- Uptake and transport of clostridial neurotoxins -- Bacillus anthracis toxins -- Large clostridial cytotoxins modifying small GTPases -- Bordetella protein toxins -- Vibrio Cholerae and Escherichia Coli thermolabile enterotoxin -- The Shiga toxins: Properties and action on cells -- Helicobacter pylori vacuolating toxin -- Pasteurella multocida toxin -- Cytolethal distending toxins -- Pseudomonas aeruginosa toxins -- Escherichia coli heat- stable enterotoxin b -- Paradigms and classification of bacterial membrane -damaging toxins -- Membrane damaging and cytotoxic phospholipases -- Bacteroides fragilis toxins -- Structure and mode of action of RTX cytolysins -- Genetics and phylogeny of RTX cytolysins -- The family of two-component cytolysins of Serratia and other -- bacteria -- Alpha-helix and Beta-barrel pore-forming toxins (leucocidins, alpha-, gamma- and -- delta-cytolysins) of Staphylococcus aureus -- Aerolysin and related Aeromonas toxins -- Clostridium septicum pore-forming alpha-toxin -- Clostridium perfringens epsilon toxin -- Repertoire and general features of the family of cholesteroldependent cytolysins -- Comparative three-dimensional structure of cholesterol-dependent cytolysins -- Perfringolysin O and Intermedilysin: mechanisms of pore formation by the -- cholesterol-dependent cytolysins -- Pneumolysin: structure, function and role in disease -- Listeriolysin -- Enterococcus faecalis cytolysin toxin -- Streptolysin S: one of the most potent and elusive of all bacterial toxins -- The group B streptococcal beta-haemolysin/cytolysin -- Haemolysins of Vibrio cholerae and other Vibrio species -- Clostridium perfringens enterotoxin -- Bacillus cereus enterotoxins, bi- and tri-component cytolysins and other -- haemolysins -- Uropathogenic Escherichia coli cytolysins -- Escherichia coli, Vibrio and Yersinia species heat-stable enterotoxins -- What are superantigens? -- Staphylococcal superantigens and the diseases they cause -- Streptococcal superantigenic toxins -- Superantigenic toxin of Yersinia pseudotuberculosis -- Comparative three-dimensional structure of bacterial superantigenic toxins -- Induction and modulation of inflammatory networks by bacterial protein toxins -- Clostridial toxins in the pathogenesis of gas gangrene -- Staphylococcal exfoliative toxins -- Medical applications of botulinum neurotoxins -- Bacterial protein toxins as food poisons -- Engineering of bacterial toxins for research and medicine -- Engineered bacterial toxin vaccines and adjuvants -- Toxins as tools -- Bacterial protein toxins as biological weapons.
504 $aIncludes bibliographical references and index.
588 0 $aPrint version record.
650 0 $aBacterial toxins.
650 6 $aToxines bacte riennes.
650 7 $aMEDICAL$xToxicology.$2bisacsh
650 7 $aBacterial toxins.$2fast$0(OCoLC)fst00825240
650 12 $aBacterial Toxins.
650 22 $aBacterial Proteins.
655 4 $aElectronic books.
655 0 $aElectronic books.
700 1 $aAlouf, J. E.$q(Joseph E.)
700 1 $aPopoff, Michel R.
776 08 $iPrint version:$tComprehensive sourcebook of bacterial protein toxins.$b3rd ed.$dAmsterdam ; Boston : Elsevier, ℗♭2006$z0120884453$z9780120884452$w(DLC) 2006271885$w(OCoLC)63177428
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856 40 $3MyiLibrary$uhttp://www.myilibrary.com?id=62846
856 40 $3Referex$uhttp://www.engineeringvillage.com/controller/servlet/OpenURL?genre=book&isbn=9780120884452$zAn electronic book accessible through the World Wide Web; click for information
856 40 $3ScienceDirect$uhttp://www.sciencedirect.com/science/book/9780120884452
856 41 $3Table of contents$uhttp://catdir.loc.gov/catdir/toc/fy0604/2006271885.html
856 42 $3Publisher description$uhttp://catdir.loc.gov/catdir/enhancements/fy0629/2006271885-d.html
856 40 $uhttps://www.sciencedirect.com/science/book/9780120884452$zAccess restricted to Stanford Community$yFulltext
856 40 $3ScienceDirect$uhttp://dproxy.library.dc-uoit.ca/login?url=https://www.sciencedirect.com/science/book/9780120884452$zeBook available for Durham College via Elsevier. Click link to access
856 40 $3ScienceDirect$uhttps://ezproxy.aub.edu.lb/login?url=http://www.sciencedirect.com/science/book/9780120884452$zClick for electronic access to e-book.
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