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LEADER: 05864cam 2200829Ia 4500
001 ocn429670925
003 OCoLC
005 20200429220418.0
008 090807s2009 ne a ob 001 0 eng d
006 m o d
007 cr mn|||||||||
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019 $a436431207$a457241807$a489104169$a646815293$a756717079$a1005744536$a1148118029
020 $a9783540896159$q(e-isbn)
020 $a3540896155$q(e-isbn)
020 $z9783540896142
020 $z3540896147
035 $a(OCoLC)429670925$z(OCoLC)436431207$z(OCoLC)457241807$z(OCoLC)489104169$z(OCoLC)646815293$z(OCoLC)756717079$z(OCoLC)1005744536$z(OCoLC)1148118029
037 $b00325391
050 4 $aQP625.A27$bA34 2009eb
060 4 $aW1$bHA51L no.193 2009
060 4 $aQU 58$bA2323 2009
072 7 $aMED$x008000$2bisacsh
082 04 $a612.015756$222
245 00 $aAdenosine receptors in health and disease /$cConstance N. Wilson, S. Jamal Mustafa, editors ; contributors, M.P. Abbracchio [and others].
260 $aDordrecht ;$aNew York :$bSpringer,$c℗♭2009.
300 $a1 online resource (xiii, 652 pages) :$billustrations
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
490 1 $aHandbook of experimental pharmacology, 0171-2004 ;$vv. 193
504 $aIncludes bibliographical references and index.
588 0 $aPrint version record.
505 0 $aTo Adenosine Receptors as Therapeutic Targets -- A1 Adenosine Receptor Antagonists, Agonists, and Allosteric Enhancers -- Recent Developments in Adenosine A2A Receptor Ligands -- Recent Developments in A2B Adenosine Receptor Ligands -- Medicinal Chemistry of the A3 Adenosine Receptor: Agonists, Antagonists, and Receptor Engineering -- Adenosine Receptors and the Heart: Role in Regulation of Coronary Blood Flow and Cardiac Electrophysiology -- Adenosine Receptors and Reperfusion Injury of the Heart -- Adenosine Receptors and Inflammation -- A1 Adenosine Receptor: Role in Diabetes and Obesity -- A3 Adenosine Receptor: Pharmacology and Role in Disease -- Adenosine Receptors and Asthma -- Adenosine Receptors, Cystic Fibrosis, and Airway Hydration -- Adenosine Receptors in Wound Healing, Fibrosis and Angiogenesis -- Adenosine Receptors and Cancer -- Adenosine Receptors and the Kidney -- Adenosine Receptors and the Central Nervous System -- Adenosine Receptors and Neurological Disease: Neuroprotection and Neurodegeneration -- Adenosine A2A Receptors and Parkinson's Disease -- Adenosine Receptor Ligands and PET Imaging of the CNS.
520 $aSince their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson's disease, multiple sclerosis, Alzheimer's disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.
650 0 $aAdenosine$xReceptors.
650 0 $aAdenosine$xPhysiological effect.
650 2 $aPurinergic P1 Receptor Antagonists.
650 2 $aPharmacokinetics.
650 2 $aReceptors, Purinergic P1$xtherapeutic use.
650 7 $aMEDICAL$xBiochemistry.$2bisacsh
650 7 $aAdenosine$xPhysiological effect.$2fast$0(OCoLC)fst00796564
650 7 $aAdenosine$xReceptors.$2fast$0(OCoLC)fst00796565
655 4 $aElectronic books.
700 1 $aWilson, Constance N.
700 1 $aMustafa, S. Jamal.
776 08 $iPrint version:$tAdenosine receptors in health and disease.$dBerlin : Springer, 2009$z3540896147$w(DLC) 2009921799$w(OCoLC)382398772
830 0 $aHandbook of experimental pharmacology ;$vv. 193.
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856 40 $3MyiLibrary$uhttp://www.myilibrary.com?id=233119
856 40 $3SpringerLink$uhttps://doi.org/10.1007/978-3-540-89615-9
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856 40 $3SpringerLink$uhttp://link.springer.com/openurl?genre=book&isbn=978-3-540-89614-2
856 40 $3SpringerLink$uhttps://link.springer.com/openurl?genre=book&isbn=978-3-540-89614-2
856 41 $3MyiLibrary, Table of contents$uhttp://www.myilibrary.com?id=233119&ref=toc
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948 $hNO HOLDINGS IN P4A - 80 OTHER HOLDINGS