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Der Hypophysen-Schilddrüsen-Regelkreis

Entwicklung und klinische Anwendung eines nichtlinearen Modells

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Last edited by ISBNbot2
July 27, 2021 | History

Der Hypophysen-Schilddrüsen-Regelkreis

Entwicklung und klinische Anwendung eines nichtlinearen Modells

  • 0 Ratings
  • 2 Want to read
  • 1 Currently reading
  • 0 Have read
Publish Date

Thyroid hormones play a central role in metbolic coordination. Robust control of thyroid homeostasis is therefore essential for survival and reproduction.

In 1940, eleven years after the discovery of the thyrotropic hormone TSH by Aron in the year 1929, W. T. Salter postulated the existence of a feedback loop linking pituitary and thyroid gland, similarly to the two gonadotropic feedback control loops that had been described shortly before. Salter's hypothesis could be proved by Astwood and Hoskins only a few years later. In 1968, Panda and Turner succeeded in a quantitative description ot the interdependence of thyroxine and TSH levels, but the first mathematical models of the feedback loop had already been developed up to 12 years earlier.

Over the years, cybernetic models of thyroid homeostasis were increasingly improved, a success that was also enabled by growing empirical data. As a consequence of this continued evolution, some of the newest models are also suitable for medical decision making.

This book is a comprehensive description of one of these novel "parametrically isomorphic" models. It describes mathematical and computational aspects of this model as well as a diagnostic tool (SPINA Thyr) that allows for evaluating the thyroid's secretory capacity (GT) and sum activity of peripheral deiodinases (GD).

Additionally, it describes reference ranges for GT and GD in a healthy population and the distributions of both structure parameters in patients suffering from selected thyroid diseases. A last section is devoted to diagnostic power of secretory capacity and deiodinase sum activity in terms of sensitivity, specificity and likelihood ratios.

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Book Details

Published in

Berlin, Germany

Table of Contents

1 Einleitung 1
2 Theoretische Grundlagen 9
2.1 Methoden der biologischen Kybernetik 9
2.2 Das Wirkungsgefüge des thyreotropen Regelkreises 18
2.3 Signale, Bausteine und Organisationsstrukturen 20
3 Entwicklung eines nichtlinearen Regelkreis-Modells 25
3.1 Einzelgleichungen der Übertragungsglieder 29
3.2 Vorhersage von Hormonkonzentrationen im Gleichgewicht 35
3.3 Rechnersimulationen 41
3.4 Parametrisierung des Modells 46
3.5 Evaluation 52
4 Deduktion eines diagnostischen Verfahrens aus dem Modell 57
4.1 SPINA - Ein Ansatz zur Ermittlung von Strukturparametern des Regelkreises 57
4.2 Design einer Diagnostikstudie für epidemiologische Grunddaten (Phase I) 59
4.3 Experimentelle Anwendung der Referenzwerte in einem retrospektiven Ansatz (Phase II) 61
4.4 Statistische Auswertung 65
4.5 Entwicklung von Software für die praktische Anwendung 66
5 Ergebnisse, Bewertung und Anwendung 69
5.1 Modellevaluation 69
5.1.1 Vorhergesagte Gleichgewichtskonzentrationen 69
5.1.2 Zeitverhalten in Ruhe 70
5.1.3 Verhalten bei Belastungen 75
5.1.4 Simulierte Funktionsstörungen 78
5.2 Methodenevaluation 87
5.2.1 Verteilung der Verhaltens- und Strukturparameter bei Gesunden und Kranken 93
5.2.2 Diagnostische Wertigkeit der Parameter 113
5.3 Berechnungs-Software 118
6 Diskussion 121
7 Zusammenfassung 133
8 Literaturverzeichnis 135
8.1 Druckwerke 135
8.2 Internet-Ressourcen und Online-Materialien 141
9 Anhang 143
9.1 Symbolverzeichnis 143
9.2 Wirkungsgefüge des Gesamtmodells 147
9.3 Ausgewählte Quelltexte der entwickelten Programme 151
9.3.1 Simulationsprogramm "SimThyr" 151
9.3.2 Rechenhilfe "SpinaThyr" 161
9.3.3 SPINA-Thyr (CGI-Version) 164
9.3.4 Berechnungsprogramm für die Korrelationsdimension "CD2" 167
9.4 Abdruck des standardisierten Anamnesebogens 175
9.5 Korrelationsgraphiken zur Berechnung der fraktalen Dimension 177
9.6 ROC-Kurven 181

Edition Notes

Spektrum medizinischer Forschung ; Bd. 2


Universal Decimal Classification

The Physical Object

VI, 188
Number of pages
20.5 x 14.5 x 1.2 centimeters
280 grams

ID Numbers

Open Library
2002 A 25878
Deutsche National Bibliothek
2002 U 1849
Bayerische Staatsbibliothek BSB-ID
0700/UMD 9532

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July 27, 2021 Edited by ISBNbot2 normalize ISBN
March 10, 2019 Edited by ImportBot import existing book
July 3, 2011 Edited by TOC improved
July 3, 2011 Edited by Table of Contents, Classifications
January 10, 2011 Created by Added new book.