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Thyroid hormones play a central role in metbolic coordination. Robust control of thyroid homeostasis is therefore essential for survival and reproduction.
In 1940, eleven years after the discovery of the thyrotropic hormone TSH by Aron in the year 1929, W. T. Salter postulated the existence of a feedback loop linking pituitary and thyroid gland, similarly to the two gonadotropic feedback control loops that had been described shortly before. Salter's hypothesis could be proved by Astwood and Hoskins only a few years later. In 1968, Panda and Turner succeeded in a quantitative description ot the interdependence of thyroxine and TSH levels, but the first mathematical models of the feedback loop had already been developed up to 12 years earlier.
Over the years, cybernetic models of thyroid homeostasis were increasingly improved, a success that was also enabled by growing empirical data. As a consequence of this continued evolution, some of the newest models are also suitable for medical decision making.
This book is a comprehensive description of one of these novel "parametrically isomorphic" models. It describes mathematical and computational aspects of this model as well as a diagnostic tool (SPINA Thyr) that allows for evaluating the thyroid's secretory capacity (GT) and sum activity of peripheral deiodinases (GD).
Additionally, it describes reference ranges for GT and GD in a healthy population and the distributions of both structure parameters in patients suffering from selected thyroid diseases. A last section is devoted to diagnostic power of secretory capacity and deiodinase sum activity in terms of sensitivity, specificity and likelihood ratios.
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Subjects
Thyroid gland, Endocrinology, Cybernetics, Medicine, Medical Cybernetics, Biomedical Cybernetics, biological cybernetics, hyperthyroidism, hypothyroidism, hyperdeiodation, hyperdeiodination, hypodeiodation, hypodeiodination, SPINA Thyr, GT, GD, Thyroid's secretory capacity, deiodinase sum activity, Schilddrüse, thyroidology, SPINA-GT, SPINA-GD, SimThyrShowing 1 featured edition. View all 1 editions?
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Der Hypophysen-Schilddrüsen-Regelkreis: Entwicklung und klinische Anwendung eines nichtlinearen Modells
2002, Logos-Verlag Berlin
Paperback
in German
3897228505 9783897228504
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Book Details
Published in
Berlin, Germany
Table of Contents
1 Einleitung | 1 | |
2 Theoretische Grundlagen | 9 | |
2.1 Methoden der biologischen Kybernetik | 9 | |
2.2 Das Wirkungsgefüge des thyreotropen Regelkreises | 18 | |
2.3 Signale, Bausteine und Organisationsstrukturen | 20 | |
3 Entwicklung eines nichtlinearen Regelkreis-Modells | 25 | |
3.1 Einzelgleichungen der Übertragungsglieder | 29 | |
3.2 Vorhersage von Hormonkonzentrationen im Gleichgewicht | 35 | |
3.3 Rechnersimulationen | 41 | |
3.4 Parametrisierung des Modells | 46 | |
3.5 Evaluation | 52 | |
4 Deduktion eines diagnostischen Verfahrens aus dem Modell | 57 | |
4.1 SPINA - Ein Ansatz zur Ermittlung von Strukturparametern des Regelkreises | 57 | |
4.2 Design einer Diagnostikstudie für epidemiologische Grunddaten (Phase I) | 59 | |
4.3 Experimentelle Anwendung der Referenzwerte in einem retrospektiven Ansatz (Phase II) | 61 | |
4.4 Statistische Auswertung | 65 | |
4.5 Entwicklung von Software für die praktische Anwendung | 66 | |
5 Ergebnisse, Bewertung und Anwendung | 69 | |
5.1 Modellevaluation | 69 | |
5.1.1 Vorhergesagte Gleichgewichtskonzentrationen | 69 | |
5.1.2 Zeitverhalten in Ruhe | 70 | |
5.1.3 Verhalten bei Belastungen | 75 | |
5.1.4 Simulierte Funktionsstörungen | 78 | |
5.2 Methodenevaluation | 87 | |
5.2.1 Verteilung der Verhaltens- und Strukturparameter bei Gesunden und Kranken | 93 | |
5.2.2 Diagnostische Wertigkeit der Parameter | 113 | |
5.3 Berechnungs-Software | 118 | |
6 Diskussion | 121 | |
7 Zusammenfassung | 133 | |
8 Literaturverzeichnis | 135 | |
8.1 Druckwerke | 135 | |
8.2 Internet-Ressourcen und Online-Materialien | 141 | |
9 Anhang | 143 | |
9.1 Symbolverzeichnis | 143 | |
9.2 Wirkungsgefüge des Gesamtmodells | 147 | |
9.3 Ausgewählte Quelltexte der entwickelten Programme | 151 | |
9.3.1 Simulationsprogramm "SimThyr" | 151 | |
9.3.2 Rechenhilfe "SpinaThyr" | 161 | |
9.3.3 SPINA-Thyr (CGI-Version) | 164 | |
9.3.4 Berechnungsprogramm für die Korrelationsdimension "CD2" | 167 | |
9.4 Abdruck des standardisierten Anamnesebogens | 175 | |
9.5 Korrelationsgraphiken zur Berechnung der fraktalen Dimension | 177 | |
9.6 ROC-Kurven | 181 |
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- Created January 10, 2011
- 15 revisions
July 27, 2021 | Edited by ISBNbot2 | normalize ISBN |
March 10, 2019 | Edited by ImportBot | import existing book |
July 3, 2011 | Edited by 80.142.51.175 | TOC improved |
July 3, 2011 | Edited by 80.142.51.175 | Table of Contents, Classifications |
January 10, 2011 | Created by 134.147.157.18 | Added new book. |