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Research in quantitative bioassay methodology and risk analysis and characterization

by: Gaver, Donald Paul.;Jacobs, Patricia A.

Publication date: 1996-07

Topics: MATHEMATICAL MODELS., CORRELATION., STATISTICAL ANALYSIS., CARCINOGENS.

Publisher: Monterey, California : Naval Postgraduate School

Collection: navalpostgraduateschoollibrary; fedlink; americana

Contributor: Naval Postgraduate School, Dudley Knox Library

Language: en_US

Cover title

"NPS-OR-96-008."

"July 1996."

AD A313 899

Includes bibliographical references (p. 14-16)

The use of canonical correlation to combine information from biological testing systems is discussed. A graphical procedure to combine results from biological test systems is proposed. Results are presented of analyses of data from health screens to monitor the health status of medaka used in toxicological studies. A statistical model that incorporates a non-ignorable missing data mechanism is proposed to study the effect of leukocrit values which are not measurable. Results are presented of analyses of pathology data from the six month interim sacrifice of the West Branch Canal Creek Carcinogenicity Study with Medaka, Test 401-002R

aq/ /aq cc:9116 01/28/97