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Cancer metastasis
David Lyden, D. R. Welch, Beth ...

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Cancer metastasis
biologic basis and therapeutics
edited by David Lyden, Danny R. Welch, Bethan Psaila

Published 2011 by Cambridge University Press in New York, NY .
Written in English.

About the Book

"Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed"--Provided by publisher.

Table of Contents

Basic research
Models and tools for metastasis studies
Animal models of cancer metastasis
Drosophilia and zebrafish: genetic models for cancer metastasis
Computational models
Intravital microscopy to visualize invasion and metastasis
Metastasis-promoting genes
Role of metastasis suppressor genes in metasis
Stromal-derived factors that dictate organ-specific metastasis
Metastasis genes: epigenetics
Germline variation and other host determinants of metastatic potential
Influence of aging and cellular senescence on metasasis
Various properties of cancer cells
Continuum of epithelial mesenchymal transition: implication of hybrid states for migration and survival in development and cancer
Apoptosis, anoikis, and senescence
Metastatic inefficiency and tumor dormancy
Stromal cells/extracellular matrix
Role of inflammation in metastatic progression
Proteolytic cascades in invasion and metastasis
Role of matrix metalloproteinases in tumor invasion and metastasis
Cell-derived microvesicles and metastasis
Systemic factors
Exploring the earliest steps in metastasis: the pre-metastatic niche
Growth regulatory pathways contributing to organ selectivity of metastasis
Determinants of organ-specific metastasis
Function and expression of the uPA/uPAR system in cancer metastasis
Lymphatics: on the route to cancer metastasis
Clinical research
Introduction to clinical research
Primary brain tumors and cerebral metastases
Head and neck cancer metastasis
Cutaneous melanoma: therapeutic approaches for metastatic disease
Gastric cancer metastasis
Metastatic pancreatic cancer
Metastasis of primary liver cancer
Advances in management of metastatic colorectal cancer
Lung cancer metastasis
Metastatic thyroid cancer: evaluation and treatment
Metastatic renal cell carcinoma
Bladder cancer
Bone complications of myeloma and lymphoma
Breast metastasis
Gynecologic malignancies
Prostate cancer metastasis: thoughts on biology and therapeutics
Biology and treatment of metastatic testicular cancer
Applications of proteomics to metastasis diagnosis and individualized therapy
Critical issues of research on circulating and disseminated tumor cells in cancer patients
Lymphatic mapping and sentinel lymph node biopsy
Molecular imaging and metastasis
Preserving bone health in malignancy and complications of bone metastases
Role of platelets and thrombin in metastasis
Cancer nanotechnology offers great promise for cancer research and therapy
Metronomic chemotherapy for treatment of metastatic disease: from preclinical research to clinical trials
Discovery and development of drugs targeting tumor invasion and metastasis
Role of radiotherapy in the treatment of metastatic disease
Prospects for clinical trials of metastasis inhibitors.

Edition Notes

Includes bibliographical references and index.

Copyright Date


Dewey Decimal Class
Library of Congress
RC269.5 .C355 2011

The Physical Object

xvii, 642 pages :
Number of pages

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Internet Archive
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