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October 21, 2010 | History

RNA interference and viruses 1 edition

RNA interference and viruses
Miguel Angel Martínez

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RNA interference and viruses
current innovations and future trends
edited by Miguel Angel Martínez

Published 2010 by Caister Academic Press in Norfolk, UK .
Written in English.

About the Book

"Since its discovery in 1998, RNA interference (RNAi) has heralded the advent of novel tools for biological research and drug discovery. This exciting new technology is emerging as a powerful modality for battling some of the most notoriously challenging viral clinical targets such as hepatitis C virus (HCV) and human immunodeficiency virus (HIV). However, several critical issues associated with this novel technology must be resolved before it can progress to testing in human clinical trials, and these have been the target of intensive research in recent years. In this book, expert RNAi specialists from around the world have teamed up to produce a timely and thought-provoking review of the area. The two central themes are: 1) the latest findings on RNAi-virus interactions and 2) progress in the development of RNAi-based antiviral therapeutics. A number of chapters explain general concepts concerned with the role of RNAi in natural antiviral defense mechanisms, other chapters discuss how to improve the efficacy and safety of RNAi-based antiviral drugs, while others describe how this technology is being developed as a new therapeutic tool for fighting specific viruses, including HIV, HCV and respiratory viruses. Authors also outline potential new avenues for research thus providing a stimulus for further research. Essential reading for researchers involved in RNAi or antiviral research and a recommended text for all virology laboratories."--Publisher's description.

Table of Contents

RNAi: an antiviral defense system in insects / Bertsy Goic and Maria-Carla Saleh
RNA silencing in plants and the role of viral suppressors / Ana Giner, Juan Jose Lopez-Moya and Lorant Lakatos
The properties and roles of virus-encoded microRNAs / Melanie Tanguy and Sebastien Pfeffer
Virus-encoded suppressors of RNA silencing and the role of cellular miRNAs in mammalian antiviral immune responses / Joost Haasnoot and Ben Berkhout
HCV and the interaction with miR-122 in the liver / Gabriele Fuchs and Cara T. Pager
Viral escape from RNAi in mammalian cells / Maria Nevot and Miguel Angel Martinez
RNAi gene therapy to control HIV-1 infection / Ben Berkhout and Olivier ter Brake
Advances in the use of RNAi to treat chronic hepatitis B virus infection / Abdullah Ely and Patrick Arbuthnot
Hepatitis C: new insights and therapeutics by RNAi / Qiuwei Pan and Luc J.W. van der Laan
RNAi applications to defeat respiratory viral infections / Sailen Barik
RNAi with viral vectors that deliver small interference RNAs / Jovanna Gonzalez-Rojas, Xabier Abad and Puri Fortes.

Edition Notes

Includes bibliographical references and index.


Library of Congress
QR395 .R573 2010

The Physical Object

vii, 252 p. :
Number of pages

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History Created October 21, 2010 · 1 revision Download catalog record: RDF / JSON

October 21, 2010 Created by ImportBot initial import