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Last edited by WorkBot
January 24, 2010 | History

Insulin resistance precipitates beta-cell dysfunction and beta-cell expansion in a non-obese model of type 2 diabetes 1 edition

Insulin resistance precipitates beta-cell dysfunction and beta-cell ex ...
Daphne Yau

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Insulin resistance precipitates beta-cell dysfunction and beta-cell expansion in a non-obese model of type 2 diabetes.

Published 2005 .
Written in English.

About the Book

Although insulin resistance and beta-cell dysfunction are the hallmarks of type 2 diabetes (T2DM), whether insulin resistance can precipitate beta-cell dysfunction without a preexisting genetic beta-cell defect is unclear. We have examined the consequences of insulin resistance on the beta-cell in the MKR mouse, which expresses the M&barbelow;CK-KR-IGF-IR transgene, a dominant-negative insulin-like growth factor-1 receptor, in muscle. In this model, dominant-negative expression led to systemic insulin resistance, hyperglycemia and defects in insulin secretion. Despite the demand on insulin secretion, MKR mice displayed increased pancreatic insulin content and beta-cell mass, the latter mediated through beta-cell hyperplasia and hypertrophy. Enhancement of insulin sensitivity improved insulin secretion and beta-cell morphology. Our studies consequently demonstrate that insulin resistance can precipitate beta-cell dysfunction and compensatory changes in the beta-cell. However, this compensation is insufficient to prevent diabetes, demonstrating a mechanism through which insulin resistance can undermine beta-cell compensation, and lead to hyperglycemia.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0738.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
113 leaves.
Number of pages
113

ID Numbers

Open Library
OL19217861M
ISBN 10
0494075082

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page