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January 24, 2010 | History

Mechanisms of insulin sensitization by omapatrilat, a vasopeptidase inhibitor, and atorvastatin, a 3-hydroxyl-3-methylglutaryl coenzyme A reductase inhibitor 1 edition

Mechanisms of insulin sensitization by omapatrilat, a vasopeptidase in ...
Victor Shing Chi Wong

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Mechanisms of insulin sensitization by omapatrilat, a vasopeptidase inhibitor, and atorvastatin, a 3-hydroxyl-3-methylglutaryl coenzyme A reductase inhibitor.

Published 2005 .
Written in English.

About the Book

In the first study, OMA treatment in Zucker fatty rats resulted in significantly lower systolic blood pressure compared to the placebo-treated group. OMA did not enhance basal or insulin-stimulated IRS-1 tyrosine phosphorylation or its association with PI3-kinase. Under basal and insulin-stimulated conditions, OMA treatment did not alter protein mass or phosphorylation of Akt/PKB, p42/44 ERK or AMPK, or total GLUT4 protein expression. These findings suggest that OMA's ability to improve insulin-stimulated muscle glucose uptake in Zucker fatty rats is not mediated by enhancing insulin or AMPK-signaling.In the second study, ATORVA treatment resulted in an improvement in whole body insulin sensitivity in both lean and fatty Zucker rats, and an increase in 2-deoxyglucose uptake by skeletal muscles (quadriceps and gastrocnemius) of the Zucker lean rats. Insulin-stimulated phosphorylation of Akt/PKB was significantly increased in skeletal muscle of ATORVA-treated lean and fatty rats. We conclude that ATORVA induces insulin sensitization in Zucker lean and fatty rats and this is associated with augmented insulin-dependent Akt/PKB phosphorylation.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0738.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (3 microfiches).

The Physical Object

Pagination
184 leaves.
Number of pages
184

ID Numbers

Open Library
OL19217857M
ISBN 10
0494075074

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page