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January 24, 2010 | History

Respiratory activation of the genioglossus muscle involves both non-NMDA and NMDA glutamate receptors at the hypoglossal motor nucleus in-vivo 1 edition

Respiratory activation of the genioglossus muscle involves both non-NM ...
Hendrick William Steenland

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Respiratory activation of the genioglossus muscle involves both non-NMDA and NMDA glutamate receptors at the hypoglossal motor nucleus in-vivo.

Published 2005 .
Written in English.

About the Book

The hypoglossal motor nucleus (HMN) transmits respiratory drive to the genioglossus (GG) muscle of the tongue. From in-vitro studies the mechanism of this transmission is thought to rely almost exclusively on non- N-methyl-D-aspartate (non-NMDA) but not NMDA glutamate receptor activation. The current study tests the hypothesis that both non-NMDA and NMDA receptors contribute to respiratory drive transmission at the HMN in-vivo. Experiments were performed in anesthetized adult rats. Microdialysis perfusion of either NMDA or non-NMDA receptor antagonists into the HMN dose-dependently reduced respiratory-related GG activity. These effects were found to be pharmacologically and regionally specific. In addition, the activities of these receptors were related to the baseline level of respiratory drive. These results show that both NMDA and non-NMDA glutamate receptors at the HMN are involved in transmission of the respiratory drive signal to the GG muscle in-vivo.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0772.

t.p.: has "Hendrik".

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
109 leaves.
Number of pages
109

ID Numbers

Open Library
OL19217839M
ISBN 10
0494075031

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page