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January 24, 2010 | History

Markers of heart failure in isolated right ventricular dysfunction among adult tetralogy of Fallot and Mustard repair of TGA patient populations 1 edition

Markers of heart failure in isolated right ventricular dysfunction amo ...
Courtney Powell

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Markers of heart failure in isolated right ventricular dysfunction among adult tetralogy of Fallot and Mustard repair of TGA patient populations.

Published 2005 .
Written in English.

About the Book

Rationale. Better understanding of the early stages of RV dysfunction in two poorly understood patient groups with poor prognosis; repaired tetralogy of Fallot (ToF) and Mustard repair of TGA (Mustard), is needed. Objectives. This study aimed to characterize neurohormones and oxidative stress (aldehydes) in ToF and Mustard patients with isolated RV dysfunction. Methods. 93 congenital cardiac patients were recruited from the TGH. The levels of the following biomarkers were compared to levels in control subjects; ANP, BNP, ET-1, Ang-11, MDA, 4-HNE, hexanal, and heptanal. Clinical parameters including, NYHA class, RV function and size were evaluated for correlations to the biomarkers. Results. ANP, BNP, hexanal, and heptanal were significantly elevated in both congenital cardiac groups. These paramenters also correlated significantly to NYHA class. Discussion. ANP and BNP can be activated by RV volume overload (ToF) or pressure overload (Mustard). Oxidative stress needs to be further evaluated in these two patient populations.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0815.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
93 leaves.
Number of pages
93

ID Numbers

Open Library
OL19217820M
ISBN 10
049407499X

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page