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Last edited by WorkBot
January 24, 2010 | History

The protective role of erythropoietin against doxorubicin-induced cardiomyopathy via PI3K-dependent pathway 1 edition

The protective role of erythropoietin against doxorubicin-induced card ...
Kyoung-Han Kim

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The protective role of erythropoietin against doxorubicin-induced cardiomyopathy via PI3K-dependent pathway.

Published 2005 .
Written in English.

About the Book

The clinical usage of antineoplastic drug doxorubicin (DOX) is limited due to cardiotoxic side effects. The cytokine erythropoietin (EPO) is critical for the production of mature red blood cells and is commonly used to treat anemia in cancer therapy. Recent experimental data reported that EPO contributes to anti-apoptosis in neuronal, vascular smooth muscle, and vascular endothelial cells. I examined whether EPO protects the heart against DOX-induced cardiomyopathy. EPO protected cultured neonatal mouse ventricular myocytes (NMVMs) against DOX-induced cell death and apoptosis. This protection by EPO correlated with increased phosphorylation of PI3K-dependent survival pathways, Akt/PKB and GSK-3beta while PI3K inhibitor LY294002 diminished EPO's protective effects. These protective actions of EPO were also observed in mice administered DOX wherein cardiac function, as assessed using echocardiography. Conclusion. This study suggests that EPO protects myocardium against DOX-induced apoptotic cell death via PI3K-dependent pathways as well as impaired heart function.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0734.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

124 leaves.
Number of pages

ID Numbers

Open Library

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page