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January 24, 2010 | History

Effects of mitochondrial dysfunction on synaptic transmission in rat hippocampal slices 1 edition

Effects of mitochondrial dysfunction on synaptic transmission in rat h ...
Eunji Ellen Kang

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Effects of mitochondrial dysfunction on synaptic transmission in rat hippocampal slices.

Published 2005 .
Written in English.

About the Book

In this study, the consequences of synaptic mitochondrial dysfunction are examined in the hippocampal CA1 region of brain slices from young (15 to 20 days) rats using a mitochondrial uncoupler, CCCP. In the presence of 10 muM CCCP or 2 muM CCCP, intracellular recordings in CA1 pyramidal cell showed a decrease in stratum radiatum evoked EPSP-IPSPs but an increase in the frequency of spontaneous EPSPs. The increase in spontaneous EPSPs were prevented with both 5 muM BAPTA-AM (with 1 mM probenecid) or 2 muM CsA. However both these drug failed to reverse the blocking effect of CCCP on the evoked EPSPs-IPSPs. Pretreatment of 1 muM FK506, a calcineurin inhibitor, did not prevent the effect of CCCP on either evoked nor spontaneous neurotransmitter release. Thus CCCP increased the spontaneous neurotransmitter release due to increased cytosolic Ca2+ and CCCP abolished evoked neurotransmitter release which Ca2+ is not solely responsible for.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0770.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

85 leaves.
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History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page