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January 24, 2010 | History

Role of SAP102 in NMDA receptor-mediated neurotoxicity 1 edition

Role of SAP102 in NMDA receptor-mediated neurotoxicity
Amy Hayashi

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Role of SAP102 in NMDA receptor-mediated neurotoxicity.

Published 2005 .
Written in English.

About the Book

TAT-NR2B9c is a peptide containing the C-terminal PDZ binding domain from the NR2 subunit can prevent excitotoxicity and is neuroprotective during ischemic damage (Aarts, M. et al., 2002). The peptide may disrupt the interaction between Postsynaptic Density Protein -95 (PSD95) and the NMDA receptor (NMDAR), thereby uncoupling NO production from NMDAR activation. An increased production of nitric oxide (NO) is thought to underlie the excitotoxicity associated with NMDAR activation. This research has identified Synapse Associated Protein-102 (SAP102), a member of the PSD95 protein family, as a key NR2B interacting protein. The knock down cultures of SAP102 showed neuroprotective effects during NMDA toxicity assays, suggesting that the protein may be involved in NMDA receptor-mediated excitotoxic signaling pathway. Furthermore, the knock down cultures contained unchanged NO production level during excitotoxicity, supporting the notion that SAP102 does not bind to nNOS and thus does not result in increased amount of NO.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0769.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

117 leaves.
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January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page