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January 24, 2010 | History

Effects of restraint stress on hypothalamic-pituitary-adrenal activity in STZ-diabetic rats 1 edition

Effects of restraint stress on hypothalamic-pituitary-adrenal activity ...
Danitza Eustolia Goche Montes

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Effects of restraint stress on hypothalamic-pituitary-adrenal activity in STZ-diabetic rats.

Published 2005 .
Written in English.

About the Book

Poor glycemic control in diabetes, as well as prolonged stress, often cause sustained glucocorticoid secretion and hypothalamic-pituitary-adrenal (HPA) hyperactivity. However, the mechanism of HPA hyperactivation in diabetes is poorly understood. We investigated molecular factors underlying alteration of HPA mediators by comparing the effects of diabetes and restraint stress (45min/d): occasional (3 intermittent episodes) and repeated (20 consecutive episodes) restraint in non-diabetic and diabetic rats. Brains and pituitaries were collected on day 21 and mRNA expression was determined by in situ hybridization. As expected, diabetic groups were hyperglycemic (21.7+/-1.5mM). 21 days of diabetes increased pro-opiomelanocortin, basal corticosterone, hippocampal MR, and adrenal weight. Occasional stress did not change baseline parameters of HPA function in non-diabetic rats. In diabetic rats, occasional and repeated stress decreased pro-opiomelanocortin, basal corticosterone, and increased sensitivity of peak corticosterone response. Normalization of HPA parameters in diabetic stressed rats could guard against the high glucocorticoid levels associated with diabetes.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0734.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

98 leaves.
Number of pages

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History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page