Click here to skip to this page's main content.

New to the Open Library? — Learn how it works
Is Open Library useful to you? Chip in to keep it growing. Your gift will be matched today!   Donate
Last edited by WorkBot
January 24, 2010 | History

Mechanisms of deep brain stimulation 1 edition

Mechanisms of deep brain stimulation
Gordon Daniel Chin

No ebook available.


Prefer the physical book? Check nearby libraries powered by WorldCat


Oh! The humanity! There's no description for this book yet. Can you help?
There is only 1 edition record, so we'll show it here...  •  Add edition?

Mechanisms of deep brain stimulation
injection and microstimulation in the pallidum of the rat.

Published 2005 .
Written in English.

About the Book

Deep brain stimulation (DBS) is a proven surgical treatment for advanced Parkinson's disease, although its mechanism of action is unknown. One theory is inhibition of neuronal firing via pre synaptic gamma-aminobutyric acid (GABA) release. To investigate this, 43 neurons in the globus pallidus (GP) of anesthetized rats were electrically stimulated before and after local microinjections (0.2--4.0 mul) of the synaptic blockers bicuculline (17 neurons) or CoCl 2 (23 neurons). Trains of high frequency stimulation (HFS) were administered (∼300 Hz, train duration 500 ms) through the recording electrode or an adjacent electrode. Prior to drug injection, four types of neuronal response to HFS were identified including inhibition or excitation. Comparison of the time to recovery of neuronal activity in neurons inhibited by HFS, pre- and post-injection, revealed that HFS induced inhibition is mediated in part by GABA binding to GABAA receptors. These results support the GABA release theory of DBS.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0768.

"MR07489".

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
122 leaves.
Number of pages
122

ID Numbers

Open Library
OL19217765M
ISBN 10
0494074892
OCLC/WorldCat
156889427

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page