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January 24, 2010 | History

Mechanisms of deep brain stimulation 1 edition

Mechanisms of deep brain stimulation
Gordon Daniel Chin

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Mechanisms of deep brain stimulation
injection and microstimulation in the pallidum of the rat.

Published 2005 .
Written in English.

About the Book

Deep brain stimulation (DBS) is a proven surgical treatment for advanced Parkinson's disease, although its mechanism of action is unknown. One theory is inhibition of neuronal firing via pre synaptic gamma-aminobutyric acid (GABA) release. To investigate this, 43 neurons in the globus pallidus (GP) of anesthetized rats were electrically stimulated before and after local microinjections (0.2--4.0 mul) of the synaptic blockers bicuculline (17 neurons) or CoCl 2 (23 neurons). Trains of high frequency stimulation (HFS) were administered (∼300 Hz, train duration 500 ms) through the recording electrode or an adjacent electrode. Prior to drug injection, four types of neuronal response to HFS were identified including inhibition or excitation. Comparison of the time to recovery of neuronal activity in neurons inhibited by HFS, pre- and post-injection, revealed that HFS induced inhibition is mediated in part by GABA binding to GABAA receptors. These results support the GABA release theory of DBS.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0768.


Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

122 leaves.
Number of pages

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January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page