Open Library logo
New Feature: You can now embed Open Library books on your website!   Learn More
Last edited by WorkBot
January 24, 2010 | History

The role of phosphatidylinositol-3 kinase isomers in myocardial ischemic preconditioning 1 edition

The role of phosphatidylinositol-3 kinase isomers in myocardial ischem ...
Kiwon Ban

No ebook available.


Prefer the physical book? Check nearby libraries with:


Buy this book


There's no description for this book yet. Can you add one?
There is only 1 edition record, so we'll show it here...  •  Add edition?

The role of phosphatidylinositol-3 kinase isomers in myocardial ischemic preconditioning.

Published 2005 .
Written in English.

About the Book

Ischemic preconditioning (IPC) is a novel cell protection mechanism whereby brief periods of sublethal ischemia can protect the myocyte from prolonged ischemia-induced-injury. Recently, several papers suggested that phosphatidylinositol-3 kinase (PI3K) plays an important role in IPC protection. Our study examined the isoform specificity of PI3K in IPC using PI3Kgamma knockout (PI3Kgamma-/-) and PI3Kalpha dominant-negative (PI3KalphaDN) mice. Recovery rate in IPC group was significantly higher than I/R group in wild type hearts. However, the protective effect of IPC was completely abolished in PI3Kgamma-/- hearts. Surprisingly, PI3KalphaDN hearts showed significant recovery after both I/R and IPC. Therefore our studies suggested that PI3Kgamma isomer is involved in IPC and genetic inhibition of PI3Kalpha is resistant against ischemia. Furthermore, examining downstream of PI3K revealed that PI3Kgamma-PKB/Akt-GSK3beta signaling cascade is critical for regulating cell survival. Selective inhibition PI3Kalpha or activation of PI3Kalpha may be novel therapeutic strategies for protecting the ischemic myocardium.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0732.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
113 leaves.
Number of pages
113

ID Numbers

Open Library
OL19217760M
ISBN 10
0494074884

History

Download catalog record: RDF / JSON
January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page