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January 24, 2010 | History

Probing acute opioid effects in bipolar disorder 1 edition

Probing acute opioid effects in bipolar disorder
Sarah A. L. Marshall


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Probing acute opioid effects in bipolar disorder.

Published 2005 .
Written in English.

About the Book

Bipolar disorder and opioid use disorders are highly co-morbid. Evidence from past opioid agonist challenge studies conducted in unipolar and bipolar depressed subjects suggest transient global improvements in depressive symptoms. It was hypothesized that persons experiencing bipolar depression would exhibit altered responses to acute opioid exposure, experiencing greater changes in mood compared to control subjects. Fifteen bipolar (8 euthymic, 7 depressed), and 10 control subjects participated in a double-blind, placebo-controlled, randomized, cross-over study. Subjective and physiological effects of hydromorphone 6 mg orally were assessed over 6 hours. Results demonstrated that bipolar I depressed subjects reported improved mood associated with hydromorphone. Adverse effects of hydromorphone negatively correlated with depression severity. These findings support the hypothesis that individuals experiencing bipolar depression may exhibit an altered response to acute hydromorphone exposure and suggest that this altered response is likely related to the state of depression rather than to the vulnerability for bipolar disorder.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0830.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

121 leaves.
Number of pages

ID Numbers

Open Library

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page