Click here to skip to this page's main content.

New to the Open Library? — Learn how it works
Last edited by WorkBot
January 24, 2010 | History

Efficacy and safety of extended-release oral morphine sulfate compared with continuous infusion of morphine sulfate in the treatment of children with painful aplastic sickle cell crises 1 edition

Efficacy and safety of extended-release oral morphine sulfate compared ...
Ernest Albert Kopecky

Read

No readable version available.

Lists

You could add Efficacy and safety of extended-release oral morphine sulfate compared with continuous infusion of morphine sulfate in the treatment of children with painful aplastic sickle cell crises to a list if you log in.
Cor blimey. There's no description for this book yet. Can you help?
There is only 1 edition record, so we'll show it here...  •  Add edition?

Efficacy and safety of extended-release oral morphine sulfate compared with continuous infusion of morphine sulfate in the treatment of children with painful aplastic sickle cell crises.

Published 2005 .
Written in English.

About the Book

Background. This work compared the efficacy and safety of oral versus intravenous morphine in children with sickle cell pain.Methods. 56 children received intravenous morphine LD≤50.15 mg/kg, followed by either oral morphine 1.9 mg/kg q12h plus intravenous placebo, or intravenous morphine 0.04 mg/kg/h, plus placebo tablet. Pain was assessed using 4 pain scales. Post-hoc analysis assessed exposure to morphine as an etiological factor for acute chest syndrome (ACS).Results. 50 children completed. Baseline demographic/physiologic characteristics were similar between groups. Mean oral morphine dose was 2.99 mg/kg/d[0.75]; mean intravenous morphine dose was 0.81 mg/kg/d[0·30]). Mean pain scores were similar for both treatment groups. With oral morphine, there was a 2-fold higher morphine AUCSS and a 3-fold higher M6G AUCSS than with CIV morphine. New onset of ACS was 3-fold more prevalent in the oral versus CIV group.Conclusions. Oral morphine provided effective analgesia. In a small subset, the risk of ACS was associated with high systemic exposure to oral morphine.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0829.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (1 microfiche).

The Physical Object

Pagination
85 leaves.
Number of pages
85

ID Numbers

Open Library
OL19217648M
ISBN 10
0494074663

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page