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January 24, 2010 | History

Microarray analysis of developmental changes in cortical gene expression 1 edition

Microarray analysis of developmental changes in cortical gene expressi ...
Mawahib O. Semeralul

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Microarray analysis of developmental changes in cortical gene expression.

Published 2005 .
Written in English.

About the Book

Dysfunction in the prefrontal cortex (PFC) has been implicated in the etiology of several late-onset neuropsychiatric disorders. The laminar structure of the PFC is established in utero, but extensive remodeling continues into adolescence. The large-scale pattern of gene transcription during post-natal development was examined in murine PFC using oligonucleotide microarrays. The observed trajectory of mRNA transcript changes during development was consistent with known morphological and biochemical events in this period. Overall, most mRNA levels decreased post-natally with the majority of change between weeks 2 and 4. The mRNA levels of genes involved in cell proliferation decreased substantially in the first 2 post-natal weeks, as post-mitotic cells in the PFC begin to differentiate. Rapid changes in mRNA levels of cytoskeletal, extracellular matrix, plasma membrane lipid, transport machinery, protein folding and regulatory genes were observed. Quantitative PCR verified the microarray results for six selected genes: Dnmt3a, Col3a1, Slc16a1, Mlp, Nid1 and Bdh.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0831.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (3 microfiches).

The Physical Object

186 leaves.
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History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page