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Heterooligomerization of the D1 and D5 dopamine receptors 1 edition

Heterooligomerization of the D1 and D5 dopamine receptors
Ryan D. Rajaram


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Heterooligomerization of the D1 and D5 dopamine receptors.

Published 2005 .
Written in English.

About the Book

Many studies have demonstrated that G-protein coupled receptors (GPCRs) form dimeric and higher order oligomeric units both in-vivo and in-vitro. A study of the two closely related D1-like receptors D1 and D5, was performed in order to determine if an association existed. Using the co-immunoprecipitation as a starting point, we have established that D1 and D5 associate. We further explored this interaction through the use of a newly developed nuclear localization signal (NLS) based assay that displayed an interaction between the D1 and D5 dopamine receptors fused to fluorophores and expressed in HEK293T cells. Additionally, a cell-surface assay was performed, demonstrating that a NLS-inserted D1 or D5 receptor could effectively co-internalize with a non-NLS receptor, suggesting that an interaction between these two receptors existed. The NLS-based assay in combination with the previous data from the co-immunoprecipitation, demonstrated that the D1 and D5 dopamine receptors could form heterooligomers.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0830.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

101 leaves.
Number of pages

ID Numbers

Open Library

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page