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January 24, 2010 | History

Development of colorectal tumours in Apc Min/+ mice 1 edition

Development of colorectal tumours in Apc Min/+ mice
Tapfuma Mutukura

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Development of colorectal tumours in Apc Min/+ mice
effects on aryl hydrocarbon receptor expression.

Published 2005 .
Written in English.

About the Book

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates induction of many drug metabolizing enzymes including cytochrome P450s (CYP1A1, CYP1A2, CYP1B1). The AhR is over-expressed in certain types of tumours, but it is unknown whether it is also over-expressed in colorectal tumours. I attempted to determine if there are changes in AhR or AhR-regulated gene expression in adenomas from C57BL/6J-Apc Min/J mice as compared to matching tissue from C57BL/6J mice. There was a significant increase in AhR mRNA in tumours from the ileum as compared to matching normal tissue from control mice in two of the four ApcMin/+ mice used. Mice which expressed increased AhR had a corresponding increase in expression of CYP1B1 and COX-2 mRNA. However, CYP1A1 expression was significantly decreased in all ileum tumors from all four ApcMin/+ mice. This work suggests that the AhR and CYP1B1 may be important as therapeutic targets against colorectal cancer.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0830.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
120 leaves.
Number of pages
120

ID Numbers

Open Library
OL19217619M
ISBN 10
0494074612

History

Download catalog record: RDF / JSON
January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page