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January 24, 2010 | History

Development of colorectal tumours in Apc Min/+ mice 1 edition

Development of colorectal tumours in Apc Min/+ mice
Tapfuma Mutukura

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Development of colorectal tumours in Apc Min/+ mice
effects on aryl hydrocarbon receptor expression.

Published 2005 .
Written in English.

About the Book

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates induction of many drug metabolizing enzymes including cytochrome P450s (CYP1A1, CYP1A2, CYP1B1). The AhR is over-expressed in certain types of tumours, but it is unknown whether it is also over-expressed in colorectal tumours. I attempted to determine if there are changes in AhR or AhR-regulated gene expression in adenomas from C57BL/6J-Apc Min/J mice as compared to matching tissue from C57BL/6J mice. There was a significant increase in AhR mRNA in tumours from the ileum as compared to matching normal tissue from control mice in two of the four ApcMin/+ mice used. Mice which expressed increased AhR had a corresponding increase in expression of CYP1B1 and COX-2 mRNA. However, CYP1A1 expression was significantly decreased in all ileum tumors from all four ApcMin/+ mice. This work suggests that the AhR and CYP1B1 may be important as therapeutic targets against colorectal cancer.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0830.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

120 leaves.
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January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page