Click here to skip to this page's main content.

New to the Open Library? — Learn how it works
Last edited by WorkBot
January 24, 2010 | History

Development of colorectal tumours in Apc Min/+ mice 1 edition

Development of colorectal tumours in Apc Min/+ mice
Tapfuma Mutukura


No readable version available.


You could add Development of colorectal tumours in Apc Min/+ mice to a list if you log in.
Heavens to Betsy! There's no description for this book yet. Can you help?
There is only 1 edition record, so we'll show it here...  •  Add edition?

Development of colorectal tumours in Apc Min/+ mice
effects on aryl hydrocarbon receptor expression.

Published 2005 .
Written in English.

About the Book

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates induction of many drug metabolizing enzymes including cytochrome P450s (CYP1A1, CYP1A2, CYP1B1). The AhR is over-expressed in certain types of tumours, but it is unknown whether it is also over-expressed in colorectal tumours. I attempted to determine if there are changes in AhR or AhR-regulated gene expression in adenomas from C57BL/6J-Apc Min/J mice as compared to matching tissue from C57BL/6J mice. There was a significant increase in AhR mRNA in tumours from the ileum as compared to matching normal tissue from control mice in two of the four ApcMin/+ mice used. Mice which expressed increased AhR had a corresponding increase in expression of CYP1B1 and COX-2 mRNA. However, CYP1A1 expression was significantly decreased in all ileum tumors from all four ApcMin/+ mice. This work suggests that the AhR and CYP1B1 may be important as therapeutic targets against colorectal cancer.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0830.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

120 leaves.
Number of pages

ID Numbers

Open Library

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page