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January 24, 2010 | History

Dysfunction of the brain reward system in apathy associated with Alzheimer's disease 1 edition

Dysfunction of the brain reward system in apathy associated with Alzhe ...
Shehnaz Moosa

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Dysfunction of the brain reward system in apathy associated with Alzheimer's disease
neuroanatomical correlates and evaluation of measures sensitive to changes induced by dextroamphetamine.

Published 2005 .
Written in English.

About the Book

The etiology of apathy in Alzheimer's disease (AD) remains to be elucidated. For this thesis, it was hypothesized that apathy was linked to dysfunction in the Brain Reward System (BRS). Two studies were conducted. In the first, 24 apathetic compared with 29 non-apathetic AD outpatients showed significant perfusion differences in key BRS areas as shown by Technetium-99m-labelled ethylcysteinate dimer (99mTc-ECD SPECT). In the second, important characteristic subjective and objective effects of a BRS stimulant were detected in five apathetic and one non-apathetic AD outpatients prior to and following a 10mg dose of dextroamphetamine. Hence, there may be an underlying dysfunction in the BRS that may lead to the manifestation of apathy in AD patients.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0830.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (3 microfiches).

The Physical Object

Pagination
225 leaves.
Number of pages
225

ID Numbers

Open Library
OL19217618M
ISBN 10
0494074604

History

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January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page