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January 24, 2010 | History

Electrophysiological effects of long chain omega-3 polyunsaturated fatty acids in rabbits in vivo 1 edition

Electrophysiological effects of long chain omega-3 polyunsaturated fat ...
Donna Monica Debicki

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Electrophysiological effects of long chain omega-3 polyunsaturated fatty acids in rabbits in vivo.

Published 2005 .
Written in English.

About the Book

The anti-arrhythmic actions of omega-3 polyunsaturated fatty acids (PUFAs) are widely documented, although the mechanism of this protection is not well understood. The primary objective was to investigate the effects of long chain omega-3 PUFAs on refractoriness, conduction velocity, and defibrillation on a healthy heart in vivo. We infused 0.77ml/kg i.v. Omegaven (EPA + DHA, n=10), Intralipid (vehicle control, n=10), or saline (n=10) over 20 minutes to anesthetised New Zealand White rabbits. Pre and post drug/vehicle treatment, we measured ventricular effective refractory period (VERP: Cycle Length=180, 160, 140msec), shortest cycle length allowing 1:1 capture (SCL), right ventricular monophasic action potential duration at 90% repolarization (MAPD90), QRS duration (stimulus to end of QRS), and QT interval (measured during ventricular pacing). Acute omega-3 PUFA administration has small but significant class III effect in vivo, decreases defibrillation threshold, and may also increase conduction velocity. This combination of effects could possibly account for their anti-arrhythmic actions.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0829.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
110 leaves.
Number of pages
110

ID Numbers

Open Library
OL19217605M
ISBN 10
0494074566

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page