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Electrophysiological effects of long chain omega-3 polyunsaturated fatty acids in rabbits in vivo 1 edition

Electrophysiological effects of long chain omega-3 polyunsaturated fat ...
Donna Monica Debicki

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Electrophysiological effects of long chain omega-3 polyunsaturated fatty acids in rabbits in vivo.

Published 2005 .
Written in English.

About the Book

The anti-arrhythmic actions of omega-3 polyunsaturated fatty acids (PUFAs) are widely documented, although the mechanism of this protection is not well understood. The primary objective was to investigate the effects of long chain omega-3 PUFAs on refractoriness, conduction velocity, and defibrillation on a healthy heart in vivo. We infused 0.77ml/kg i.v. Omegaven (EPA + DHA, n=10), Intralipid (vehicle control, n=10), or saline (n=10) over 20 minutes to anesthetised New Zealand White rabbits. Pre and post drug/vehicle treatment, we measured ventricular effective refractory period (VERP: Cycle Length=180, 160, 140msec), shortest cycle length allowing 1:1 capture (SCL), right ventricular monophasic action potential duration at 90% repolarization (MAPD90), QRS duration (stimulus to end of QRS), and QT interval (measured during ventricular pacing). Acute omega-3 PUFA administration has small but significant class III effect in vivo, decreases defibrillation threshold, and may also increase conduction velocity. This combination of effects could possibly account for their anti-arrhythmic actions.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0829.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

110 leaves.
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