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January 24, 2010 | History

The effects of reduced folate receptor expression on intestinal tumorigenesis in the ApcMin/+ model 1 edition

The effects of reduced folate receptor expression on intestinal tumori ...
Nancy Pragosa

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The effects of reduced folate receptor expression on intestinal tumorigenesis in the ApcMin/+ model.

Published 2005 .
Written in English.

About the Book

Folate status has been shown to be inversely associated with colorectal cancer risk. Recently developed murine models of folate receptor, or folate binding protein (Folbp), deficiency indicate that Folbp1 is critical in folate homeostasis.These findings support the dual effect of folic acid supplementation on intestinal tumorigenesis observed in other chemical and genetic models of colorectal cancer.ApcMin/+Folbp1 +/- and ApcMin /+Folbp1+/+ mice were used to determine whether Folbp1+/- would increase intestinal tumorigenesis and whether this could be reversed by folic acid supplementation. We demonstrated that Folbp1+/- reduced blood and small intestinal mucosal folate concentrations at 2.5 months, which was reversed by folic acid supplementation, but did not affect blood folate concentrations at 4 months. The Folbp1 genotype did not modulate intestinal tumorigenesis in ApcMin/+ mice. However, folate status was inversely associated with proximal and mid small intestinal tumorigenesis, whereas Hcy was inversely associated with distal small intestinal and colonic tumorigenesis.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0823.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (3 microfiches).

The Physical Object

189 leaves.
Number of pages

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Open Library

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page