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January 24, 2010 | History

The modulatory effects of folate deficiency on mRNA and/or protein expression of the genes involved in folate metabolism and one-carbon transfer reactions using an in vitro folate deficient model of colorectal cancer 1 edition

The modulatory effects of folate deficiency on mRNA and/or protein exp ...
Inki Hayashi

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The modulatory effects of folate deficiency on mRNA and/or protein expression of the genes involved in folate metabolism and one-carbon transfer reactions using an in vitro folate deficient model of colorectal cancer.

Published 2005 .
Written in English.

About the Book

Although studies have shown an inverse relationship between folate intake and colorectal cancer risk, the mechanisms by which folate deficiency may modulate colorectal cancer risk have not been established. An in vitro model of folate deficiency was used to determine the effects of folate deficiency on mRNA and/or protein expression of the genes involved in folate metabolism and one-carbon transfer reactions (GCP-II, FR, RFC, FPGS, GGH, MTR, MTRR, MTHFR, DHFR, TS, cSHMT, DNMT-1, -3a, -3b and DeMTase). The results showed complex and, in some cases, cell-specific effects of folate deficiency on mRNA and/or protein expression of these genes. This study provides a frame work for future studies investigating the modulatory effects of folate deficiency on the proteins and enzymes involved in folate metabolism and one-carbon transfer reactions.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0820.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
181 leaves.
Number of pages
181

ID Numbers

Open Library
OL19217532M
ISBN 10
0494074426

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page