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January 24, 2010 | History

Effect of estrogen on glutamate-induced neuronal cell death and calcium influx 1 edition

Effect of estrogen on glutamate-induced neuronal cell death and calciu ...
Joel Perrella

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Effect of estrogen on glutamate-induced neuronal cell death and calcium influx.

Published 2005 .
Written in English.

About the Book

High concentrations of glutamate can cause neuronal cell death and this involves changes in the regulation of cellular calcium (Ca 2+) through the N-methyl-D-aspartate (NMDA) receptor and subsequent activation of nitric oxide synthase (NOS). Estrogen has been shown to protect against glutamate-induced cell death possibly by a reduction in the excitotoxic Ca2+ influx. In the present study, the effect of 17beta-estradiol (17beta-E2) and a more potent antioxidant estrogen, Delta8,17beta-estradiol (Delta8,17beta-E2) on cell viability and intracellular Ca 2+ ([Ca2+]i) on glutamate-induced cell death was studied. Estrogens, 17beta-E2 and Delta8,17beta-E 2, significantly protected against glutamate-induced excitotoxicity with 17beta-E2 being more potent than Delta8,17beta-E 2. The neuroprotective effect of estrogens in cortical cells occurs through a mechanism that does not involve a reduction of [Ca2+] i. This is to our knowledge a first such observation. Whether decreases in NOS related products, such as peroxynitrite, is one mechanism by which estrogens provide neuroprotection against glutamate-induced excitotoxicity, remains to be investigated.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0765.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
162 leaves.
Number of pages
162

ID Numbers

Open Library
OL19217485M
ISBN 10
0494074337

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page