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January 24, 2010 | History

The effects of folate deficiency on gene expression in human colorectal adenocarcinoma cell lines 1 edition

The effects of folate deficiency on gene expression in human colorecta ...
Petar Novakovic

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The effects of folate deficiency on gene expression in human colorectal adenocarcinoma cell lines.

Published 2005 .
Written in English.

About the Book

Folate is a B vitamin that inversely modulates colorectal carcinogenesis. Folate status is also an important determinant in chemotherapeutic response. Mediating the transfer of one-carbon moieties is the sole biochemical function known for folate, and in this role folate plays a critical role in DNA synthesis, repair and methylation. In vitro models of folate deficiency were used to determine the effects of folate deficiency on gene expression in several human colorectal cancer cell lines. Folate deficiency altered the expression patterns of genes found to be involved in metabolism, intracellular signalling, cell cycle, DNA repair, transcriptional regulation, angiogenesis, cell adhesion, transport, and cytoskeletal organization and microtubule-based movement, in a cell-specific manner. These studies provide insight into the specific molecular targets of folate deficiency, and therefore will allow for a better understanding of the mechanism of action associated with the folate depletion-enhanced cytotoxicity on cancer cells.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0764.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
181 leaves.
Number of pages
181

ID Numbers

Open Library
OL19217481M
ISBN 10
0494074329

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page