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January 24, 2010 | History

The role of fibrinogen-like protein 2 (FGL2)/fibroleukin in the pathogenesis of experimental autoimmune arthritis 1 edition

The role of fibrinogen-like protein 2 (FGL2)/fibroleukin in the pathog ...
Megan Cara Melnyk

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The role of fibrinogen-like protein 2 (FGL2)/fibroleukin in the pathogenesis of experimental autoimmune arthritis.

Published 2005 .
Written in English.

About the Book

Fibrin deposition is a prominent feature and major contributor to the pathogenesis of RA. Fibrinogen-like protein 2 (fgl2) is an inducible prothrombinase that plays an important role in fibrin deposition during viral hepatitis and cytokine-induced fetal loss. CIA in DBA/1 mice revealed that fgl2 mRNA transcripts and protein were markedly upregulated in arthritic joints. Fibrin deposition was prominent within the synovial lining and articular joint space, in close association with fgl2 expression. Infusion of murine CD200Fc inhibited the development of CIA and expression of fgl2 mRNA transcripts and protein in DBA/1 mice. The decrease in fgl2 expression was also associated with inhibition of fibrin deposition. Development of collagen type II monoclonal antibody-induced arthritis was inhibited in fgl2-/- mice in comparison to fgl2+/+ mice, which developed a severe inflammatory arthritis with clinical and m2 histological manifestations associated with RA. These observations suggest that fgl2 contributes to fibrin deposition in RA and provides a rationale for targeting fgl2 to ameliorate RA.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0812.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

113 leaves.
Number of pages

ID Numbers

Open Library

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page