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January 24, 2010 | History

Activating the cAMP-PKA pathway modulates genioglossus muscle and responses to excitatory inputs 1 edition

Activating the cAMP-PKA pathway modulates genioglossus muscle and resp ...
Cynthia R. A. Aoki

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Activating the cAMP-PKA pathway modulates genioglossus muscle and responses to excitatory inputs.

Published 2005 .
Written in English.

About the Book

Whether modulation of intracellular pathways increases pharyngeal muscle activity has not been investigated but is relevant to treat obstructive sleep apnea. This study determines whether modulating cyclic-adenosine-3'-5'-monophosphate (cAMP) at the hypoglossal motor nucleus (HMN) increases genioglossus (GG) muscle activity across sleep-wake states. Electrodes were implanted to record sleep-wake states and respiratory muscle activity. Microdialysis probes were inserted into the HMN to perfuse artificial-cerebrospinal-fluid (ACSF) alone or with forskolin (adenylyl cyclase activator to increase cAMP), a cAMP analogue, or iso-butyl-methylxanthine (IBMX, phosphodiesterase inhibitor to prevent breakdown of CAMP). Compared to ACSF, forskolin and the CAMP analogue increased GG activity during wakefulness and non-REM sleep but not REM sleep. IBMX did not affect GG activity but selectively abolished responses to serotonin and phenylephrine and preserved responses to (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)-propionic acid, AMPA. These effects were mimicked by a cGMP analogue. In conclusion, modulating the cAMP pathway altered GG activity and responses to excitatory inputs.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0768.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
118 leaves.
Number of pages
118

ID Numbers

Open Library
OL19217434M
ISBN 10
0494074213

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page