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January 24, 2010 | History

E75, a Drosophila nuclear receptor, regulates metamorphosis through two parallel signaling pathways 1 edition

E75, a Drosophila nuclear receptor, regulates metamorphosis through tw ...
Kelly V. Yee

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E75, a Drosophila nuclear receptor, regulates metamorphosis through two parallel signaling pathways.

Published 2005 .
Written in English.

About the Book

Nuclear receptors (NRs), a class of eukaryotic transcription factors, are important for the development of D. melanogaster, particularly during metamorphosis. This process is triggered by ecdysone and juvenile hormones and the NRs that they regulate. Expression of the NR gene E75 is upregulated by both hormones, and its activity is regulated by nitric oxide (NO). In order to understand E75's function and its response to NO, I studied the expression of E75 and its heterodimerization partner DHR3 in response to ectopic expression of two E75 isoforms and nitric oxide synthase (NOS), a NO source. Ectopic expression of NOS was shown to negatively regulate E75A and E75B transcription without affecting DHR3. Also, E75B was shown to be a negative regulator of E75A and E75C and E75A to upregulate E75C . Taken together, these results suggest that E75 serves a dual purpose, potentiating ecdysone synthesis and relaying juvenile hormone signals to hinder metamorphosis.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0767.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (1 microfiche).

The Physical Object

50 leaves.
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History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page