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Neuronal function of cytoplasmic linker protein CLIP-115 1 edition

Neuronal function of cytoplasmic linker protein CLIP-115
Amanda Wai Yee Lo


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Neuronal function of cytoplasmic linker protein CLIP-115.

Published 2005 .
Written in English.

About the Book

Cytoplasmic Linker Protein-115 (CLIP-115) is encoded by the gene CYLN2, which is hemizygously deleted in patients with Williams-Beuren Syndrome (WBS). Phenotype-genotype correlation with patient data and the behaviour of Cyln2 knockout mice suggest that CLIP-115 has an essential role in normal neuronal functions. Therefore, its role in neurite formation was examined by interfering with its normal protein function via overexpression of several CLIP-115 fragments in a neuronal cell line, and analyzing parameters that were related to neurite formation (total neurite length and number, and neurite branching). Overexpression of CLIP-115 full length protein seemed to increase both neurite length and number, whereas overexpressing CLASP interacting domain of CLIP-115 might have negative effect on neurite length. Cells expressing full length CLIP-115 had a significantly higher frequency of being multinucleated, suggesting that similar to its homologue CLIP-170, and its interacting partner CLASP, CLIP-115 also functions in the process of cell division and cytokinesis.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0763.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

163 leaves.
Number of pages

ID Numbers

Open Library

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page