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January 24, 2010 | History

Neuronal function of cytoplasmic linker protein CLIP-115 1 edition

Neuronal function of cytoplasmic linker protein CLIP-115
Amanda Wai Yee Lo

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Neuronal function of cytoplasmic linker protein CLIP-115.

Published 2005 .
Written in English.

About the Book

Cytoplasmic Linker Protein-115 (CLIP-115) is encoded by the gene CYLN2, which is hemizygously deleted in patients with Williams-Beuren Syndrome (WBS). Phenotype-genotype correlation with patient data and the behaviour of Cyln2 knockout mice suggest that CLIP-115 has an essential role in normal neuronal functions. Therefore, its role in neurite formation was examined by interfering with its normal protein function via overexpression of several CLIP-115 fragments in a neuronal cell line, and analyzing parameters that were related to neurite formation (total neurite length and number, and neurite branching). Overexpression of CLIP-115 full length protein seemed to increase both neurite length and number, whereas overexpressing CLASP interacting domain of CLIP-115 might have negative effect on neurite length. Cells expressing full length CLIP-115 had a significantly higher frequency of being multinucleated, suggesting that similar to its homologue CLIP-170, and its interacting partner CLASP, CLIP-115 also functions in the process of cell division and cytokinesis.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0763.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

163 leaves.
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January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page