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January 24, 2010 | History

The distribution of the anti-cancer drug doxorubicin in relation to blood vessels and regions of hypoxia in solid tumours 1 edition

The distribution of the anti-cancer drug doxorubicin in relation to bl ...
Andrew J. Primeau

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The distribution of the anti-cancer drug doxorubicin in relation to blood vessels and regions of hypoxia in solid tumours.

Published 2005 .
Written in English.

About the Book

Anti-cancer drugs gain access to solid tumours via the circulatory system, and must penetrate tissue to kill the cancer cells. Quantitative immunofluorescence is used to study the distribution of doxorubicin in relation to blood vessels and hypoxic regions of murine 16C and EMT6 tumours and human prostate cancer PC-3 xenografts. The concentration of doxorubicin decreases exponentially with distance from tumor blood vessels, falling to half its perivascular concentration at a distance of about 40--50 mum. The mean distance from blood vessels to regions of hypoxia is 90--140 mum. Many viable tumor cells are not exposed to detectable concentrations of drug following injection. Limited distribution of doxorubicin in solid tumours is an important and neglected cause of clinical resistance that is amenable to modification. The technique described here can be adapted to studying the distribution of other drugs within solid tumours and the effect of strategies to modify their distribution.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0779.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
94 leaves.
Number of pages
94

ID Numbers

Open Library
OL19217275M
ISBN 10
0494073861

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page