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Last edited by WorkBot
January 24, 2010 | History

Early gene expression profile in mouse brain after exposure to clinically relevant doses of ionizing radiation 1 edition

Early gene expression profile in mouse brain after exposure to clinica ...
Ashraf Shawky Mahmoud-Ahmed

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Early gene expression profile in mouse brain after exposure to clinically relevant doses of ionizing radiation.

Published 2005 .
Written in English.

About the Book

This data provides the basis for further research to delineate the role of novel genes in XRT-induced CNS injury. JAK3 will be studied as a potential neuro-protective target from XRT injury.The possibility of damaging the central nervous system (CNS) is a major problem in clinical radiation treatment (XRT). Using cDNA microarray, we studied global gene expression in mouse brain within 24 h following clinically relevant doses of XRT.Early response of mouse brain to XRT is a complex process that involves dose- and time-dependent expression of hundreds of genes and modulates different molecular functions and pathways. Genes involved in signal transduction, metabolism, structural proteins, transcription, and cell cycle were modulated by XRT in mouse brain. Using real time PCR, we confirmed changes in expression of DNA fragmentation factor, beta subunit, nuclease sensitive element binding protein 1, Janus kinase3 (JAK3), and Telomeric repeat binding factor 1. Upregulation of JAK3 expression was demonstrated by immunohistochemistry.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0779.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
153 leaves.
Number of pages
153

ID Numbers

Open Library
OL19217267M
ISBN 10
0494073853

History

Download catalog record: RDF / JSON
January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page