Click here to skip to this page's main content.

New to the Open Library? — Learn how it works
Last edited by WorkBot
January 24, 2010 | History

Further investigation of the role of Fli-1 in haematopoiesis using a conditional transgenic mouse model 1 edition

Further investigation of the role of Fli-1 in haematopoiesis using a c ...
Christina Rebecca Lee

Read

No readable version available.

Lists

You could add Further investigation of the role of Fli-1 in haematopoiesis using a conditional transgenic mouse model to a list if you log in.
Fiddlesticks. There's no description for this book yet. Can you help?
There is only 1 edition record, so we'll show it here...  •  Add edition?

Further investigation of the role of Fli-1 in haematopoiesis using a conditional transgenic mouse model.

Published 2005 .
Written in English.

About the Book

The ets transcription factor Fli-1 is essential for murine vascular development and is important for the development of lymphocytes, erythrocytes, megakaryocytes, granulocytes and monocytes. More importantly, Fli-1 plays roles in various murine and human cancers, warranting further investigation into its natural and pathological functions.A tissue-specific Fli-1 overexpressing transgenic mouse model was generated using the Cre-loxP system, in which exogenous Fli-1 expression can be traced by the green fluorescence gene. Overexpression in haematopoietic and endothelial tissue caused a partial block in the development of EGFP+ double negative (CD8-/CD4-) thymocytes. Furthermore, Fli-1 overexpressing splenic T and B cells showed a marked decrease in proliferation after mitogenic stimuli. This indicates that both T cell development and proliferation are tightly controlled by ETS transcription factors; it is necessary to examine the other members of this family in the EGFP+ and negative cells from these mice, in addition to analyzing other haematopoietic lineages for appropriate markers and function.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0779.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (1 microfiche).

The Physical Object

Pagination
57 leaves.
Number of pages
57

ID Numbers

Open Library
OL19217262M
ISBN 10
0494073845

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page