Click here to skip to this page's main content.

New to the Open Library? — Learn how it works
Last edited by WorkBot
January 24, 2010 | History

Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder 1 edition

Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder
Sevag Kaladchibachi

Read

No readable version available.

Lists

You could add Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder to a list if you log in.
Crikey! There's no description for this book yet. Can you help?
There is only 1 edition record, so we'll show it here...  •  Add edition?

Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder
a molecular link in the therapeutic action of lithium.

Published 2005 .
Written in English.

About the Book

Bipolar disorder (BPD) is characterized by recurring states of mania and depression. In addition to mood imbalances, subjects often suffer from circadian disturbances. Glycogen synthase kinase 3 (GSK3), an essential kinase with widespread roles in development, cell survival, and metabolism has been demonstrated to be an essential component of the Drosophila circadian clock. These results demonstrate that genetic depletion of GSK3 in synchronized mouse embryonic fibroblasts results in a significant delay in the cycling period of mPer2. Furthermore, pharmacological inhibition of GSK3 activity by Kenpaullone, a known antagonist of GSK3 activity, as well as by lithium, a direct inhibitor of GSK3 and the most common treatment for BPD, induces a phase delay in clock gene transcriptional profiles that phenocopies GSK3 knockdown. These results confirm GSK3 as a plausible target of lithium action in BPD therapeutics, and suggest the circadian clock mechanism as a significant modulator of lithium's clinical benefits.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0763.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
85 leaves.
Number of pages
85

ID Numbers

Open Library
OL19217257M
ISBN 10
0494073837

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page