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January 24, 2010 | History

Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder 1 edition

Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder
Sevag Kaladchibachi

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Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder
a molecular link in the therapeutic action of lithium.

Published 2005 .
Written in English.

About the Book

Bipolar disorder (BPD) is characterized by recurring states of mania and depression. In addition to mood imbalances, subjects often suffer from circadian disturbances. Glycogen synthase kinase 3 (GSK3), an essential kinase with widespread roles in development, cell survival, and metabolism has been demonstrated to be an essential component of the Drosophila circadian clock. These results demonstrate that genetic depletion of GSK3 in synchronized mouse embryonic fibroblasts results in a significant delay in the cycling period of mPer2. Furthermore, pharmacological inhibition of GSK3 activity by Kenpaullone, a known antagonist of GSK3 activity, as well as by lithium, a direct inhibitor of GSK3 and the most common treatment for BPD, induces a phase delay in clock gene transcriptional profiles that phenocopies GSK3 knockdown. These results confirm GSK3 as a plausible target of lithium action in BPD therapeutics, and suggest the circadian clock mechanism as a significant modulator of lithium's clinical benefits.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0763.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

85 leaves.
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