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January 24, 2010 | History

Amino acids as endogenous inhibitors of alkaline phosphatase 1 edition

Amino acids as endogenous inhibitors of alkaline phosphatase
Pauline So

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Amino acids as endogenous inhibitors of alkaline phosphatase
implication for calcium pyrophosphate dihydrate crystal deposition disease.

Published 2005 .
Written in English.

About the Book

Calcium pyrophosphate crystal deposition disease (CPPD) is a common arthritis of the elderly in which calcium pyrophosphate dihydrate (CPPD) crystals are deposited within articular joints. The pathogenesis of the disease is unknown, but altered alkaline phosphatase (ALP) activity could be a contributing factor. In this research, the hypothesis that some endogenous molecules can inhibit ALP's pyrophosphatase (PPiase) and CPPD crystal dissolution activities was tested. Using enzyme kinetic studies, arginine, lysine, histidine and cysteine, which are inhibitors of ALP's phosphatase (Piase) activity at alkaline pH, were examined for their effects on ALP's Piase, PPiase and CPPD crystal dissolution activities at physiologic pH. Specific activities and kinetic parameters V max, KM, KI and I50 indicated that these amino acids, especially cysteine, inhibited ALP under physiologic conditions. Theses results suggest that certain amino acids, by inhibiting ALP activity, contribute to the pathogenesis of CPPD if they accumulate within the articular cartilage.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0766.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

138 leaves.
Number of pages

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January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page