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January 24, 2010 | History

An investigation of bone marrow stromal stem cells for gene therapy in X-linked Alport Syndrome 1 edition

An investigation of bone marrow stromal stem cells for gene therapy in ...
Julie Ann Perry

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An investigation of bone marrow stromal stem cells for gene therapy in X-linked Alport Syndrome.

Published 2005 .
Written in English.

About the Book

The use of bone marrow stem cells (BMSCs) was investigated for gene therapy of X-linked Alport Syndrome. Alport syndrome is a progressive nephropathy resulting from loss of the alpha3/alpha4/alpha5 network of type IV collagen from the glomerular basement membrane. Type IV collagen includes six homologous chains, alpha1-alpha6, encoded by COL4A1 to COL4A6, respectively. X-linked Alport syndrome results from a mutation in the COL4A5 gene. In this thesis, it was shown that BMSCs undergo a degree of podocytic differentiation when grown on a type IV collagen matrix in vitro. Podocytes are the cells responsible for production of the alpha3/alpha4/alpha5 network in vivo. BMSCs were able to express the alpha5 chain after infection with an adenoviral vector carrying an alpha5 transgene. In vivo , BMSCs consistently homed in the glomerular capillaries when directly infused into the kidney. These results indicate that BMSCs may be useful for gene therapy of Alport Syndrome.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0743.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
152 leaves.
Number of pages
152

ID Numbers

Open Library
OL19217224M
ISBN 10
0494073764

History

Download catalog record: RDF / JSON
January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page