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January 24, 2010 | History

Human kallikrein 5 (hK5) 1 edition

Human kallikrein 5 (hK5)
Iacovos P. Michael


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Human kallikrein 5 (hK5)
iochemical and physiological characterization.

Published 2005 .
Written in English.

About the Book

Human kallikrein 5 (hK5; encoded by the KLK5 gene) is a novel serine protease, predicted to have trypsin-like activity. Given that hK5 is differentially expressed in cancer and members of the human kallikrein family require cleavage of their propeptides by a trypsin-like serine protease, we hypothesized that hK5 may be implicated in tumour progression, and be a member of an enzymatic cascade pathway. In this study, recombinant hK5 was produced and shown to have trypsin-like activity, with preference or Arg over Lys for the P1 position. Its activity was inhibited by alpha 2-antiplasmin, antithrombin, alpha2-macroglobulin, SPINK5, and zinc. Extracellular matrix components, along with plasminogen, vitronectin, kininogen, fibrinogen, insulin-like growth factor binding proteins and semenogelins, were identified as putative physiological substrates of hK5. Finally, hK5 was able to activate and inactivate prohK2 and prohK3. We conclude that hK5 may be involved in an enzymatic cascade pathway and in tumour progression.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0764.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

131 leaves.
Number of pages

ID Numbers

Open Library

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page