Click here to skip to this page's main content.

New Feature: You can now embed Open Library books on your website!   Learn More
Last edited by WorkBot
January 24, 2010 | History

The effects of ionizing radiation on the activation of [beta]-catenin and Tcf-dependent signaling 1 edition

The effects of ionizing radiation on the activation of [beta]-catenin ...
Ananta Gurung

No ebook available.


Prefer the physical book? Check nearby libraries powered by WorldCat


Buy this book


Jeepers. There's no description for this book yet. Can you help?
There is only 1 edition record, so we'll show it here...  •  Add edition?

The effects of ionizing radiation on the activation of [beta]-catenin and Tcf-dependent signaling.

Published 2005 .
Written in English.

About the Book

Radiotherapy is associated with a risk of skin complications, including fibrosis and deficient wound healing. Beta-catenin mediated Tcf-dependent transcription is transiently activated in fibroblasts during the proliferative phase of wound healing. Surprisingly, 5Gy ionizing radiation increased beta-catenin protein levels, and it's transcriptional activity in fibroblasts. In the presence of Mg132, beta-catenin protein levels increased following irradiation suggesting a proteasomal independent mechanism. However, in the presence cycloheximide, beta-catenin protein levels did not increase following irradiation suggesting a translational dependent mechanism. Following irradiation phopho-Ser9-GSK3-beta protein levels increased, and in the presence of Dkk1, there was no elevation in beta-catenin protein, suggesting activation through the canonical wnt signaling pathway. Furthermore, irradiated beta-catenin stabilized primary fibroblasts had greater number of cells entering S-phase. Since hyperactivity of beta-catenin mediated Tcf-dependent transcription can cause hypertrophic wounds, it is possible that the increase in beta-catenin with irradiation is partly responsible for the phenomenon of radiation induced fibrosis.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0762.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (1 microfiche).

The Physical Object

Pagination
82 leaves.
Number of pages
82

ID Numbers

Open Library
OL19217200M
ISBN 10
0494073713

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page