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January 24, 2010 | History

Investigating a role for the ubiquitin ligase Itch in lymphocyte development 1 edition

Investigating a role for the ubiquitin ligase Itch in lymphocyte devel ...
Derek B. Smith

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Investigating a role for the ubiquitin ligase Itch in lymphocyte development.

Published 2005 .
Written in English.

About the Book

Within the process of lymphocyte differentiation, activation of the Notch signaling pathway specifies the T cell lineage and disallows development along the default B cell pathway. Notch signaling is tightly controlled, and regulators of the Notch pathway exert dramatic effects on the T/B lineage decision in developing lymphocytes. The E3 ubiquitin ligase Itch has been shown to bind and ubiqutinate Notch1, but the consequences of this interaction have not been described. We demonstrate that Itch is expressed in fetal liver hematopoietic progenitor cells and thymocytes and upregulated in response to Notch signaling. Overexpression of Itch in hematopoietic progenitor cells co-cultured with OP9-DL1 stromal cells subtly inhibits T cell development and promotes B cell development suggesting inhibition of Notch signaling. Itch overexpression appears to diminish the rate of Notch1 degradation. These results suggest a role for the ubiquitin ligase Itch in antagonizing Notch signaling during lymphocyte development through a non-degradative mechanism.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0813.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (1 microfiche).

The Physical Object

63 leaves.
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History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page