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January 24, 2010 | History

Failure of immunoglobulin heavy and light chain pairing and consequences for cell death in the bursa of Fabricius 1 edition

Failure of immunoglobulin heavy and light chain pairing and consequenc ...
Anton Neschadim

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Failure of immunoglobulin heavy and light chain pairing and consequences for cell death in the bursa of Fabricius.

Published 2005 .
Written in English.

About the Book

The majority of lymphocytes generated post-hatch in the bursa of Fabricius do not emigrate to the periphery, but die by apoptosis in situ. Lymphocytes that are subsequently induced to undergo apoptosis lose their surface immunoglobulin expression. Furthermore, it has been shown that loss of surface immunoglobulin expression precedes bursal cell death in vivo. We have uncovered a novel mechanism operating in the bursa of Fabricius that offers an explanation for the loss of surface immunoglobulin expression by developing bursal cells. The pre-immune repertoire in the bursa is generated by the process of somatic gene conversion. The efficiency with which this process maintains the reading frame of newly generated immunoglobulin variable-region sequences exceeds 97%. However, we demonstrated that one third of immunoglobulin variable-region sequences introduced by the ongoing gene conversion in the bursa encode heavy and light chain variable domains that preclude their association on the protein level and result in lack of surface immunoglobulin expression.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0813.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
116 leaves.
Number of pages
116

ID Numbers

Open Library
OL19217165M
ISBN 10
0494073233

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page