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January 24, 2010 | History

Expression of Notch receptors and ligands in lymphoid tissues 1 edition

Expression of Notch receptors and ligands in lymphoid tissues
Kira Cretegny

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Expression of Notch receptors and ligands in lymphoid tissues.

Published 2005 .
Written in English.

About the Book

Notch signaling has been shown to play important roles during hematopoiesis. However, a clear understanding of the expression pattern of Notch family genes is still to be determined. Although expression of Notch receptors and ligands has been detected in a very broad range of tissues, the findings were often contradictory. I have addressed this question by assessing beta-galactosidase (beta-gal) expression in several reporter strains of mice: Dll1+/lacZ , Notch2+/lacZ, Notch3+/lacZ, and MFng lacZ/lacZ. I detected lacZ expression by flow cytometry using di-beta-D-galactopyranoside (FDG), a fluorogenic beta-gal substrate, to stain viable cells based on their lacZ expression. Using this method I was able to detect beta-gal in subsets of lymphoid and myeloid cells from Notch2+/lacZ, Notch3 +/lacZ and MFnglacZ/lacZ mice. In particular, I detected high beta-gal expression in activated T and B cell from Notch2+/lacZ mice, suggesting a role for Notch2 in T and B cells activation and/or proliferation.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0812.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
114 leaves.
Number of pages
114

ID Numbers

Open Library
OL19217152M
ISBN 10
0494073209

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page