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January 24, 2010 | History

Expression of Notch receptors and ligands in lymphoid tissues 1 edition

Expression of Notch receptors and ligands in lymphoid tissues
Kira Cretegny

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Expression of Notch receptors and ligands in lymphoid tissues.

Published 2005 .
Written in English.

About the Book

Notch signaling has been shown to play important roles during hematopoiesis. However, a clear understanding of the expression pattern of Notch family genes is still to be determined. Although expression of Notch receptors and ligands has been detected in a very broad range of tissues, the findings were often contradictory. I have addressed this question by assessing beta-galactosidase (beta-gal) expression in several reporter strains of mice: Dll1+/lacZ , Notch2+/lacZ, Notch3+/lacZ, and MFng lacZ/lacZ. I detected lacZ expression by flow cytometry using di-beta-D-galactopyranoside (FDG), a fluorogenic beta-gal substrate, to stain viable cells based on their lacZ expression. Using this method I was able to detect beta-gal in subsets of lymphoid and myeloid cells from Notch2+/lacZ, Notch3 +/lacZ and MFnglacZ/lacZ mice. In particular, I detected high beta-gal expression in activated T and B cell from Notch2+/lacZ mice, suggesting a role for Notch2 in T and B cells activation and/or proliferation.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0812.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

114 leaves.
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History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page