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January 24, 2010 | History

Comparison of amitriptyline and placebo for the reduction of pain in children with polyarticular juvenile rheumatoid arthritis using serial N-of-1 trials to estimate population effect 1 edition

Comparison of amitriptyline and placebo for the reduction of pain in c ...
Adam M. Huber

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Comparison of amitriptyline and placebo for the reduction of pain in children with polyarticular juvenile rheumatoid arthritis using serial N-of-1 trials to estimate population effect.

Published 2005 .
Written in English.

About the Book

Research questions. (1) Does low-dose amitriptyline in children aged 10-18 with active polyarticular-course juvenile rheumatoid arthritis reduce pain? (2) Can N-of-1 trials analyzed with Bayesian methods be used to estimate the population effect of a treatment?Results. The treatment effect was 0.68 cm (s.d. 0.84, 95% credible interval -0.92, 2.46). The probability that it was <0 was 0.16.Methods. Six children (4 females, 10.3-16.3 years) were enrolled. There were 3 pairs of randomized, double-blinded treatments (amitriptyline 25 mg or placebo). Each treatment lasted 2 weeks, with a 1 week washout. The primary outcome was pain, measured by 10 cm visual analogue scale. Assessments were at the beginning and end of each treatment. A Bayesian statistical model was used to determine the treatment effect. Values <0 indicated superiority of amitriptyline.Conclusions. There was no evidence that amitriptyline reduced pain in these subjects. Bayesian methods were used successfully to estimate population effects.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0837.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
136 leaves.
Number of pages
136

ID Numbers

Open Library
OL19217120M
ISBN 10
0494073144

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page