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January 24, 2010 | History

Prognostic factors for first clinical fracture in patients with primary osteoporosis 1 edition

Prognostic factors for first clinical fracture in patients with primar ...
Olga Gajic-Veljanoski

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Prognostic factors for first clinical fracture in patients with primary osteoporosis
analyses of data from the Canadian Database of Osteoporosis and Osteopenia.

Published 2005 .
Written in English.

About the Book

Much research has delineated risk factors for osteoporotic fractures while the clinical course and prognosis of osteoporosis remain unexplored. Using data from the Canadian Database of Osteoporosis and Osteopenia, we examined time-to-first clinical fracture during a 30-month follow-up and prognostic factors for first clinical fracture in an inception cohort of 1142 female and male patients aged 40 years and over, with bone mineral density-diagnosed primary osteoporosis and no history of clinical fracture.The cohort, followed for 27 516 person-months, had a 5.08% cumulative fracture incidence or a fracture rate of 10.9/1000 person-months. The multivariable Cox regression complete case analysis revealed two significant prognostic factors: increasing age (Hazard Ratio (HR) = 1.03, 95% CI: 1.01-1.06) and lack of osteoporosis drug treatment (HR = 3.69, 95% CI: 1.94-7.01). Although slight bias toward informative censoring was detected, sensitivity analyses demonstrated no drastic distortions in the parameter estimates, confirming the findings of the complete case analysis.

Edition Notes

Source: Masters Abstracts International, Volume: 44-02, page: 0835.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).

The Physical Object

Pagination
174 leaves.
Number of pages
174

ID Numbers

Open Library
OL19217118M
ISBN 10
0494073136

History Created December 11, 2009 · 2 revisions Download catalog record: RDF / JSON

January 24, 2010 Edited by WorkBot add more information to works
December 11, 2009 Created by WorkBot add works page